PMID- 15991801
OWN - NLM
STAT- MEDLINE
DCOM- 20051123
LR  - 20151119
IS  - 1433-6510 (Print)
IS  - 1433-6510 (Linking)
VI  - 51
IP  - 5-6
DP  - 2005
TI  - Anti-oxLDL antibodies--marker for arterial thromboses in antiphospholipid 
      syndrome?
PG  - 279-83
AB  - Antibodies against oxidized low-density lipoproteins (anti-oxLDL antibodies) are 
      involved in the development of atherosclerosis in animal models, but their role 
      in humans is not clear. The aim of this study was to explore the relationship 
      between the presence of anti-oxLDL antibodies and the presence of 
      anti-beta2glycoprotein I (beta2gpI) antibodies, anticardiolipin antibodies and 
      lupus anticoagulant. We also analyzed the relationship between the appearance of 
      anti-oxLDL antibodies and clinical signs of antiphospholipid syndrome. This study 
      included three groups of patients: 27 patients with primary antiphospholipid 
      syndrome, 20 with secondary antiphospholipid syndrome associated with systemic 
      lupus erythematosus and 13 patients with systemic lupus erythematosus. Levels of 
      anti-oxLDL, anticardiolipin and anti-beta2gpI antibodies were detected by ELISA. 
      The presence of lupus anticoagulant was detected by coagulation tests. We found 
      that the presence of anti-oxLDL antibodies was associated with a history of 
      arterial thromboses in patients with secondary antiphospholipid syndrome (chi2 = 
      8.89, p < 0.01) and in patients with primary antiphospholipid syndrome (chi2 = 
      4.64, p < 0.05). Also, the appearance of anti-oxLDL antibodies was associated 
      with the presence of anti-beta2gpI antibodies (chi2 = 4.25, p < 0.05), which was 
      not dependent on diagnosis. These preliminary observations have to be confirmed 
      in a larger study.
FAU - Becarevic, Mirjana
AU  - Becarevic M
AD  - Institute for Medical Biochemistry, Clinical Center of Serbia, Belgrade. 
      myrjanab@yahoo.co.uk
FAU - Andrejevic, Sladana
AU  - Andrejevic S
FAU - Bonaci-Nikolic, Branka
AU  - Bonaci-Nikolic B
FAU - Obradovic, Ivana
AU  - Obradovic I
FAU - Miljic, Predrag
AU  - Miljic P
FAU - Majkic-Singh, Nada
AU  - Majkic-Singh N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Clin Lab
JT  - Clinical laboratory
JID - 9705611
RN  - 0 (Antibodies, Anticardiolipin)
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (Glycoproteins)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (Lupus Coagulation Inhibitor)
RN  - 0 (beta 2-Glycoprotein I)
RN  - 0 (oxidized low density lipoprotein)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antibodies, Anticardiolipin/analysis
MH  - Antiphospholipid Syndrome/blood/*complications/etiology
MH  - Arterial Occlusive Diseases/*diagnosis
MH  - Autoantibodies/*blood
MH  - Biomarkers/blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Glycoproteins/immunology
MH  - Humans
MH  - Lipoproteins, LDL/*immunology
MH  - Lupus Coagulation Inhibitor/analysis
MH  - Male
MH  - Middle Aged
MH  - Thrombosis/*diagnosis/etiology
MH  - beta 2-Glycoprotein I
EDAT- 2005/07/05 09:00
MHDA- 2005/12/13 09:00
CRDT- 2005/07/05 09:00
PHST- 2005/07/05 09:00 [pubmed]
PHST- 2005/12/13 09:00 [medline]
PHST- 2005/07/05 09:00 [entrez]
PST - ppublish
SO  - Clin Lab. 2005;51(5-6):279-83.