PMID- 15993278
OWN - NLM
STAT- MEDLINE
DCOM- 20050804
LR  - 20061115
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 160
IP  - 2
DP  - 2005 Jul 15
TI  - Prognostic significance of del(20q) in patients with hematological malignancies.
PG  - 188-92
AB  - Deletions of the long arm of chromosome 20 represent a common chromosomal 
      abnormality associated with myeloid malignancies, in particular with 
      myeloproliferative disorders (MPD), myelodysplastic syndromes (MDS), and acute 
      myeloid leukemia (AML). Using G-banding cytogenetic techniques, we found clones 
      with del(20q) in 36 patients with hematological malignancies examined in our 
      laboratory during the years 2001-2003: in 23 patients as a sole cytogenetic 
      aberration and in 13 patients together with other chromosomal changes. 
      Fluorescence in situ hybridization (FISH) with a probe specific for the 20q12 
      region was used in all cases to confirm the presence of the clone with deletion. 
      For patients with additional or complex chromosomal rearrangements, multicolor 
      FISH (M-FISH) analysis was performed. Statistical evaluation of the prognostic 
      impact of sex, age, diagnosis, and karyotype was performed. The survival time 
      correlated with the type of chromosomal aberration; no significant differences in 
      survival were found for sex, age, and diagnosis.
FAU - Brezinova, Jana
AU  - Brezinova J
AD  - Institute of Hematology and Blood Transfusion, U Nemocnice 1, 128 20 Prague 2, 
      Czech Republic. brez@uhkt.cz
FAU - Zemanova, Zuzana
AU  - Zemanova Z
FAU - Ransdorfova, Sarka
AU  - Ransdorfova S
FAU - Sindelarova, Lenka
AU  - Sindelarova L
FAU - Siskova, Magda
AU  - Siskova M
FAU - Neuwirtova, Radana
AU  - Neuwirtova R
FAU - Cermak, Jaroslav
AU  - Cermak J
FAU - Michalova, Kyra
AU  - Michalova K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Acute Disease
MH  - Aged
MH  - Chromosome Banding
MH  - *Chromosome Deletion
MH  - Chromosomes, Human, Pair 20/*genetics
MH  - Female
MH  - Hematologic Neoplasms/*diagnosis/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Myeloid/diagnosis/genetics
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/diagnosis/genetics
MH  - Myeloproliferative Disorders/diagnosis/genetics
MH  - Prognosis
MH  - Survival Rate
EDAT- 2005/07/05 09:00
MHDA- 2005/08/05 09:00
CRDT- 2005/07/05 09:00
PHST- 2004/08/10 00:00 [received]
PHST- 2004/12/29 00:00 [revised]
PHST- 2004/12/30 00:00 [accepted]
PHST- 2005/07/05 09:00 [pubmed]
PHST- 2005/08/05 09:00 [medline]
PHST- 2005/07/05 09:00 [entrez]
AID - S0165-4608(05)00016-6 [pii]
AID - 10.1016/j.cancergencyto.2004.12.019 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2005 Jul 15;160(2):188-92. doi: 
      10.1016/j.cancergencyto.2004.12.019.