PMID- 15993515
OWN - NLM
STAT- MEDLINE
DCOM- 20060727
LR  - 20131121
IS  - 0197-4580 (Print)
IS  - 0197-4580 (Linking)
VI  - 27
IP  - 7
DP  - 2006 Jul
TI  - Activity changes and marked stereotypic behavior precede Abeta pathology in 
      TgCRND8 Alzheimer mice.
PG  - 955-64
AB  - Alzheimer's disease (AD) is not only characterized by cognitive decline and 
      neuropathological changes, but also by non-cognitive behavioral symptoms like 
      restlessness, sleep disturbance, and wandering. These symptoms are categorized in 
      the "Behavioral and Psychological Symptoms of Dementia" (BPSD). We investigated 
      transgenic and wildtype mice of an APP transgenic mouse model of AD (TgCRND8) 
      with respect to 24 h activity and spontaneous home cage behavior at 30, 60, 90 
      and 120 days of age. At all test days, transgenic and wildtype animals differed 
      significantly with respect to activity patterns. In addition, activity rhythms 
      changed distinctly in transgenic mice with increasing age. Transgenic mice also 
      clearly showed more stereotypic behavior, which correlated significantly at 90 
      and 120 days of age with elevated corticosterone metabolite concentrations in 
      fecal samples. Activity patterns in TgCRND8 mice resemble altered rhythms of 
      activity in AD patients. Stereotypic behaviors may be caused by the same 
      mechanisms as non-cognitive behavioral symptoms of AD. Thus, it is likely that 
      analogies to BPSD that precede Abeta pathology are found in APP-overexpressing 
      TgCRND8 mice.
FAU - Ambree, Oliver
AU  - Ambree O
AD  - Department of Behavioural Biology, University of Munster, Badestr. 9, D-48149 
      Munster, Germany. ambree@uni-muenster.de
FAU - Touma, Chadi
AU  - Touma C
FAU - Gortz, Nicole
AU  - Gortz N
FAU - Keyvani, Kathy
AU  - Keyvani K
FAU - Paulus, Werner
AU  - Paulus W
FAU - Palme, Rupert
AU  - Palme R
FAU - Sachser, Norbert
AU  - Sachser N
LA  - eng
PT  - Journal Article
DEP - 20050701
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Adrenal Medulla/metabolism/physiopathology
MH  - Aging/genetics/metabolism/pathology
MH  - Alzheimer Disease/genetics/*physiopathology/psychology
MH  - Amyloid beta-Protein Precursor/metabolism
MH  - Animals
MH  - Behavior, Animal/physiology
MH  - Brain/metabolism/*pathology/*physiopathology
MH  - Circadian Rhythm/*genetics
MH  - Corticosterone/metabolism
MH  - Disease Models, Animal
MH  - Humans
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Motor Activity/*genetics
MH  - Plaque, Amyloid/genetics/metabolism/pathology
MH  - Stereotyped Behavior/*physiology
MH  - Tyrosine 3-Monooxygenase/metabolism
EDAT- 2005/07/05 09:00
MHDA- 2006/07/28 09:00
CRDT- 2005/07/05 09:00
PHST- 2005/03/02 00:00 [received]
PHST- 2005/05/03 00:00 [revised]
PHST- 2005/05/11 00:00 [accepted]
PHST- 2005/07/05 09:00 [pubmed]
PHST- 2006/07/28 09:00 [medline]
PHST- 2005/07/05 09:00 [entrez]
AID - S0197-4580(05)00145-4 [pii]
AID - 10.1016/j.neurobiolaging.2005.05.009 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2006 Jul;27(7):955-64. doi: 
      10.1016/j.neurobiolaging.2005.05.009. Epub 2005 Jul 1.