PMID- 15993714
OWN - NLM
STAT- MEDLINE
DCOM- 20051018
LR  - 20111117
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 66
IP  - 6
DP  - 2005 Jun
TI  - Linkage disequilibrium between human leukocyte antigen (HLA) class II and 
      HLA-G--possible implications for human reproduction and autoimmune disease.
PG  - 688-99
AB  - A line of investigation indicates that one or several genes in the human major 
      histocompatibility complex (MHC) influences reproductive success. Studies have 
      revealed associations between human leukocyte antigen (HLA) class II genes and 
      risk of recurrent spontaneous abortion (RSA) and pre-eclampsia. However, these 
      genes are not expressed at the feto-maternal interface. Furthermore, associations 
      between polymorphisms in the nonclassical HLA class Ib gene, HLA-G, and 
      reproductive outcome have been demonstrated. HLA-G is expressed by extravillous 
      trophoblast during pregnancy, making it a more obvious candidate gene for a 
      possible influence on pregnancy outcome. HLA-G has immunomodulatory functions. We 
      have studied linkage disequilibrium between HLA class II genes, primarily 
      HLA-DRB1 alleles, and HLA-G alleles in women with RSA and their partners (n = 
      103) and in control women and their partners (n = 92). We found a significant 
      linkage disequilibrium between HLA-DR3 and HLA-G*010102 in both the RSA and 
      control populations. For all four studied HLA loci, the alleles in the haplotype 
      HLA-DRB1*03.DQA1*05.DQB1*02.G*010102 was in clear linkage disequilibrium. This 
      HLA haplotype has repeatedly been associated with different autoimmune diseases 
      but also with RSA. The G*010102 allele includes a 14-bp sequence polymorphism in 
      the 3' untranslated region of the gene, which has been associated with 
      differences in HLA-G mRNA alternative splicing and stability. This 14-bp 
      polymorphism has also been associated with RSA, pre-eclampsia, and outcome of in 
      vitro fertilization. Implications of HLA polymorphism--and other polymorphic 
      genes in the MHC for pregnancy outcome--and for autoimmune diseases during 
      pregnancy are discussed.
FAU - Hviid, Thomas Vauvert F
AU  - Hviid TV
AD  - Department of Clinical Biochemistry, Copenhagen University Hospital, 
      Rigshospitalet, Copenhagen, Denmark. hviid@dadlnet.dk
FAU - Christiansen, Ole B
AU  - Christiansen OB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ alpha-Chains)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQA1 antigen)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR3 Antigen)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Abortion, Habitual/*genetics
MH  - Alleles
MH  - Autoimmune Diseases/*genetics/immunology
MH  - Female
MH  - Fertility/genetics
MH  - Genetic Predisposition to Disease
MH  - HLA Antigens/*genetics
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DQ alpha-Chains
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DR3 Antigen/genetics
MH  - HLA-DRB1 Chains
MH  - HLA-G Antigens
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - *Linkage Disequilibrium
MH  - Male
MH  - Pregnancy
MH  - Pregnancy Complications
EDAT- 2005/07/05 09:00
MHDA- 2005/10/19 09:00
CRDT- 2005/07/05 09:00
PHST- 2004/12/10 00:00 [received]
PHST- 2005/03/03 00:00 [revised]
PHST- 2005/03/09 00:00 [accepted]
PHST- 2005/07/05 09:00 [pubmed]
PHST- 2005/10/19 09:00 [medline]
PHST- 2005/07/05 09:00 [entrez]
AID - S0198-8859(05)00065-0 [pii]
AID - 10.1016/j.humimm.2005.03.003 [doi]
PST - ppublish
SO  - Hum Immunol. 2005 Jun;66(6):688-99. doi: 10.1016/j.humimm.2005.03.003.