PMID- 15993717
OWN - NLM
STAT- MEDLINE
DCOM- 20051018
LR  - 20081121
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 66
IP  - 6
DP  - 2005 Jun
TI  - Association of the matrix metalloproteinase-3 (MMP-3) promoter polymorphism with 
      celiac disease in male subjects.
PG  - 716-20
AB  - Matrix metalloproteinases (MMPs), such as stromelysin-1 (MMP-3), are a family of 
      enzymes important in resorption and remodeling of the extracellular matrix whose 
      degradation may play a role in the villous atrophy characteristic of celiac 
      disease (CD). We investigated the association between the polymorphism at 
      position -1171 of the MMP-3 gene and susceptibility to CD in 225 Italian patients 
      and 170 controls previously typed for human leukocyte antigen (HLA) class II 
      genes. We also evaluated sex differences in the effect of this polymorphism on 
      disease risk. A male-specific association of the 5A/6A polymorphism with CD was 
      observed. The frequencies of 6A allele and 6A/6A genotype in affected male 
      subjects were significantly above those observed both in male controls (p = 4.1 x 
      10(-3) and p = 3.4 x 10(-3); odds ratio = 2.4, 95% confidence interval 1.3-4.3) 
      and in female patients (p = 2.7 x 10(-4) and p = 6.2 x 10(-4)). This is the first 
      demonstration of a sex-specific association between the MMP-3 promoter 
      polymorphism and CD. Homozygosity for the 6A allele appears as a risk factor for 
      CD only in men, which is different from the HLA susceptibility alleles that 
      confer a higher risk in women.
FAU - Mora, Barbara
AU  - Mora B
AD  - Department of Experimental Medicine and Pathology, University of Rome La 
      Sapienza, Rome, Italy.
FAU - Bonamico, Margherita
AU  - Bonamico M
FAU - Ferri, Mirella
AU  - Ferri M
FAU - Megiorni, Francesca
AU  - Megiorni F
FAU - Osborn, John
AU  - Osborn J
FAU - Pizzuti, Antonio
AU  - Pizzuti A
FAU - Mazzilli, Maria Cristina
AU  - Mazzilli MC
LA  - eng
PT  - Journal Article
DEP - 20050318
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-DQ Antigens)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Case-Control Studies
MH  - Celiac Disease/enzymology/*genetics/physiopathology
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DQ Antigens/genetics
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/*genetics
MH  - Polymorphism, Genetic
MH  - Promoter Regions, Genetic
MH  - Sex Factors
EDAT- 2005/07/05 09:00
MHDA- 2005/10/19 09:00
CRDT- 2005/07/05 09:00
PHST- 2004/09/21 00:00 [received]
PHST- 2005/02/07 00:00 [revised]
PHST- 2005/02/11 00:00 [accepted]
PHST- 2005/07/05 09:00 [pubmed]
PHST- 2005/10/19 09:00 [medline]
PHST- 2005/07/05 09:00 [entrez]
AID - S0198-8859(05)00050-9 [pii]
AID - 10.1016/j.humimm.2005.02.005 [doi]
PST - ppublish
SO  - Hum Immunol. 2005 Jun;66(6):716-20. doi: 10.1016/j.humimm.2005.02.005. Epub 2005 
      Mar 18.