PMID- 15993720
OWN - NLM
STAT- MEDLINE
DCOM- 20051018
LR  - 20061115
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 66
IP  - 6
DP  - 2005 Jun
TI  - Association of HLA-DR and -DQ genes with Graves disease in Koreans.
PG  - 741-7
AB  - Graves disease (GD) is an autoimmune thyroid disease and is associated with human 
      leukocyte antigen (HLA)-DR3 and DQA1*0501 in Caucasians. However, the association 
      of HLA with GD is less clear-cut in East Asian populations. We analyzed HLA-DRB1 
      and -DQB1 associations with GD in 198 Korean patients compared with 200 healthy 
      controls. HLA-DRB1*0803 (27.8% vs. 14.5% in controls, OR = 2.27, corrected p 
      [p(c)] = 0.03) and *1602 (5.1% vs. 0%, OR = 22.34, p(c) = 0.03) alleles and 
      closely linked haplotypes, DRB1*0803-DQB1*0601 and DRB1*1602-DQB1*0502, conferred 
      susceptibility to GD in Koreans. Weak association of DRB1*0301 with GD 
      susceptibility was observed in male patients only (12.5% vs. 3.5%, OR = 3.57, p < 
      0.05). HLA-DRB1*0101, *0701, *1202, and *1302 alleles were weakly associated with 
      resistance to the disease (OR < 0.5, p < 0.05). Some HLA alleles were weakly 
      associated with clinical characteristics in GD patients. Patients with 
      DRB1*1301-DQB1*0603 developed their diseases in younger ages and were more 
      frequently associated with larger goiter (p < 0.05). Although HLA class II 
      alleles associated with GD in Koreans were different from those in Caucasians, 
      some associations are shared, such as association of DRB1*0301 in male patients 
      and protective effect of DRB1*0701 to GD susceptibility.
FAU - Park, Myoung Hee
AU  - Park MH
AD  - Department of Laboratory Medicine, Seoul National University College of Medicine 
      and Clinical Research Institute, Seoul National University Hospital, Seoul, 
      Korea.
FAU - Park, Young Joo
AU  - Park YJ
FAU - Song, Eun Young
AU  - Song EY
FAU - Park, Hyejin
AU  - Park H
FAU - Kim, Tae Yong
AU  - Kim TY
FAU - Park, Do Joon
AU  - Park DJ
FAU - Park, Kyong Soo
AU  - Park KS
FAU - Cho, Bo Youn
AU  - Cho BY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Female
MH  - Gene Frequency
MH  - Graves Disease/ethnology/*genetics/physiopathology
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - Humans
MH  - Korea/ethnology
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single-Stranded Conformational
EDAT- 2005/07/05 09:00
MHDA- 2005/10/19 09:00
CRDT- 2005/07/05 09:00
PHST- 2004/09/13 00:00 [received]
PHST- 2005/02/25 00:00 [revised]
PHST- 2005/03/01 00:00 [accepted]
PHST- 2005/07/05 09:00 [pubmed]
PHST- 2005/10/19 09:00 [medline]
PHST- 2005/07/05 09:00 [entrez]
AID - S0198-8859(05)00062-5 [pii]
AID - 10.1016/j.humimm.2005.03.001 [doi]
PST - ppublish
SO  - Hum Immunol. 2005 Jun;66(6):741-7. doi: 10.1016/j.humimm.2005.03.001.