PMID- 15994392
OWN - NLM
STAT- MEDLINE
DCOM- 20051018
LR  - 20171116
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 26
IP  - 1
DP  - 2005 Jul
TI  - Characterisation of natural killer cells and CD56+ T-cells in sarcoidosis 
      patients.
PG  - 77-85
AB  - The aim of the current study was to investigate the frequency, phenotype and 
      functional activity of natural killer (NK) cells and CD56+ T-cells in the 
      bronchoalveolar lavage fluid and peripheral blood of patients with pulmonary 
      sarcoidosis when compared with healthy volunteers, using staining with a panel of 
      monoclonal antibodies followed by flow cytometry. The results revealed that the 
      majority of the lung NK cell subpopulation expressed CD56(bright). In contrast, 
      there was a predominant CD56(dim) subset in the blood of both patients and 
      healthy controls. Most lung NK cells expressed C-type lectin-like human leukocyte 
      antigen (HLA)-E-specific inhibitory receptor (i.e. CD94/NKG2A), but only a few 
      lung NK cells expressed killer cell immunoglobulin-like inhibitory receptors 
      specific for HLA-A, -B or -C molecules. In addition, a significantly increased 
      number of CD56+ T-cells were observed in the blood of patients when compared with 
      controls. Upon in vitro stimulation, both lung NK and CD56+ T-cells produced 
      considerable amounts of interferon-gamma and tumour necrosis factor-alpha. Thus, 
      in the lungs of patients with pulmonary sarcoidosis, a distinct phenotype of 
      natural killer cells with the capacity to produce cytokines and actively 
      participate in the T-helper 1-like inflammatory response associated with 
      sarcoidosis was identified.
FAU - Katchar, K
AU  - Katchar K
AD  - Dept of Medicine, Division of Respiratory Medicine, Karolinska Hospital, 
      Stockholm, Sweden. kkatchar@bidmc.harvard.edu
FAU - Soderstrom, K
AU  - Soderstrom K
FAU - Wahlstrom, J
AU  - Wahlstrom J
FAU - Eklund, A
AU  - Eklund A
FAU - Grunewald, J
AU  - Grunewald J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 0 (CD56 Antigen)
RN  - 0 (Inflammation Mediators)
SB  - IM
CIN - Eur Respir J. 2006 Mar;27(3):654. PMID: 16507870
MH  - Adult
MH  - Bronchoalveolar Lavage Fluid/*cytology
MH  - CD56 Antigen/analysis/genetics/*metabolism
MH  - Case-Control Studies
MH  - Cells, Cultured
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - Inflammation Mediators/analysis/*metabolism
MH  - Killer Cells, Natural/*metabolism
MH  - Lymphocyte Activation
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Prognosis
MH  - Reference Values
MH  - Risk Assessment
MH  - Sarcoidosis, Pulmonary/*diagnosis/metabolism
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
MH  - T-Lymphocytes/metabolism
EDAT- 2005/07/05 09:00
MHDA- 2005/10/19 09:00
CRDT- 2005/07/05 09:00
PHST- 2005/07/05 09:00 [pubmed]
PHST- 2005/10/19 09:00 [medline]
PHST- 2005/07/05 09:00 [entrez]
AID - 26/1/77 [pii]
AID - 10.1183/09031936.05.00030805 [doi]
PST - ppublish
SO  - Eur Respir J. 2005 Jul;26(1):77-85. doi: 10.1183/09031936.05.00030805.