PMID- 15994633
OWN - NLM
STAT- MEDLINE
DCOM- 20050811
LR  - 20181201
IS  - 0029-7844 (Print)
IS  - 0029-7844 (Linking)
VI  - 106
IP  - 1
DP  - 2005 Jul
TI  - Immunogenetic determinants of preeclampsia and related pregnancy disorders: a 
      systematic review.
PG  - 162-72
AB  - OBJECTIVE: We sought to systematically review the impact of immunogenetic 
      factors, specifically human leukocyte antigen (HLA) allele frequencies, maternal 
      homozygosity, couple sharing, and maternal-fetal sharing, on the risk of 
      preeclampsia and intrauterine growth restriction. DATA SOURCES: A computerized 
      search of PubMed databases from 1975 to 2003 was performed with the terms 
      "preeclampsia," "eclampsia," "intrauterine growth restriction," and "human 
      leukocyte antigens" and limited to studies of human subjects in English. No 
      restrictions were placed on study design. All bibliographies were 
      cross-referenced to identify additional pertinent studies. METHODS OF STUDY 
      SELECTION: Titles and abstracts were reviewed carefully. Observational and basic 
      science research studies were selected if their main objective was to assess the 
      relationship of any aspect of HLA genotypes with preeclampsia and related 
      disorders of pregnancy. TABULATION, INTEGRATION, AND RESULTS: Data were 
      abstracted and tabulated from 22 original research studies. Meta-analytic 
      techniques were not performed owing to variations in disease and exposure 
      definitions as well as research methodologies. Studies that examined maternal, 
      paternal, and fetal HLA allele frequencies, maternal homozygosity, and couple 
      sharing yielded inconsistent results. Although the cumulative evidence points to 
      the HLA-DR locus (particularly DR4) as a correlate of preeclampsia, it remains 
      unclear whether any specific HLA allele, haplotype, or susceptibility gene in 
      linkage disequilibrium with the HLA region is responsible. Although genetic 
      evidence is suggestive of gene-gene interaction between mother and fetus, few 
      studies have evaluated the influence of maternal-fetal HLA sharing. CONCLUSION: 
      In the early 1990s, HLA genotypes were dismissed as possible etiologic factors 
      for preeclampsia, based on studies that are heterogeneous with respect to study 
      design, outcome, and exposure assessment. Many of these studies did not take into 
      account the interactions between maternal, paternal, and infant genotypes. Thus, 
      adequately powered studies designed specifically to assess the effect of 
      maternal-fetal HLA sharing on risk of preeclampsia are needed.
FAU - Saftlas, Audrey F
AU  - Saftlas AF
AD  - Department of Epidemiology, College of Public Health, University of Iowa, Iowa 
      City, 52242, USA. audrey-saftlas@uiowa.edu
FAU - Beydoun, Hind
AU  - Beydoun H
FAU - Triche, Elizabeth
AU  - Triche E
LA  - eng
GR  - R01-HD-325790/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PT  - Systematic Review
PL  - United States
TA  - Obstet Gynecol
JT  - Obstetrics and gynecology
JID - 0401101
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Female
MH  - Fetal Growth Retardation/*genetics/immunology
MH  - Genetic Predisposition to Disease/*epidemiology
MH  - HLA Antigens/*genetics/immunology
MH  - HLA-DR Antigens/*genetics/immunology
MH  - Humans
MH  - *Immunogenetics
MH  - Maternal Age
MH  - Parity
MH  - Pre-Eclampsia/*genetics/immunology
MH  - Pregnancy
MH  - Prognosis
MH  - Risk Factors
MH  - Sensitivity and Specificity
RF  - 59
EDAT- 2005/07/05 09:00
MHDA- 2005/08/12 09:00
CRDT- 2005/07/05 09:00
PHST- 2005/07/05 09:00 [pubmed]
PHST- 2005/08/12 09:00 [medline]
PHST- 2005/07/05 09:00 [entrez]
AID - 106/1/162 [pii]
AID - 10.1097/01.AOG.0000167389.97019.37 [doi]
PST - ppublish
SO  - Obstet Gynecol. 2005 Jul;106(1):162-72. doi: 10.1097/01.AOG.0000167389.97019.37.