PMID- 15995509
OWN - NLM
STAT- MEDLINE
DCOM- 20050901
LR  - 20061115
IS  - 0023-852X (Print)
IS  - 0023-852X (Linking)
VI  - 115
IP  - 7
DP  - 2005 Jul
TI  - Aberrant EGFR and chromosome 7 associate with outcome in laryngeal cancer.
PG  - 1212-8
AB  - OBJECTIVES/HYPOTHESIS: Epidermal growth factor receptor (EGFR) over-expression 
      has been reported as a prognostic indicator in laryngeal cancer; however, the 
      association with disease outcome has been inconsistent among studies. Here, we 
      use fluorescence in situ hybridization (FISH) in addition to immunohistochemistry 
      to assess laryngeal squamous cell carcinoma (SCC) to determine whether FISH can 
      better predict patient outcome. STUDY DESIGN: Retrospective study on 59 patients 
      presenting with advanced disease. METHODS: EGFR and chromosome 7 genomic statuses 
      were measured using FISH, and EGFR expression was assessed by 
      immunohistochemistry on formalin-fixed, paraffin-embedded specimens and 
      correlated with outcome in the 59 patients. RESULTS: EGFR expression was 
      marginally associated with outcome, whereas both EGFR and chromosome 7 FISH 
      status were significantly associated with outcome, and the combination of EGFR 
      and chromosome 7 FISH status provided the strongest association of any two 
      combined parameters (P = .0004). Combining EGFR expression with EGFR and 
      chromosome 7 FISH status provided further improvement (P > .0001). CONCLUSIONS: 
      Measurements of EGFR and chromosome 7 FISH status, and to a lesser extent EGFR 
      expression, have potential value in treatment planning for patients with 
      laryngeal SCC.
FAU - Morrison, Larry E
AU  - Morrison LE
AD  - Vysis, Inc., Research and Development, Downers Grove, Illinois 60515, USA. 
      larry.morrison@abbott.com
FAU - Jacobson, Kristine K
AU  - Jacobson KK
FAU - Friedman, Michael
AU  - Friedman M
FAU - Schroeder, James W
AU  - Schroeder JW
FAU - Coon, John S
AU  - Coon JS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Chromosome Aberrations
MH  - Chromosomes, Human, Pair 7/*genetics
MH  - Female
MH  - Genes, erbB-1/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Laryngeal Neoplasms/*genetics/*mortality/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Retrospective Studies
MH  - Survival Rate
EDAT- 2005/07/05 09:00
MHDA- 2005/09/02 09:00
CRDT- 2005/07/05 09:00
PHST- 2005/07/05 09:00 [pubmed]
PHST- 2005/09/02 09:00 [medline]
PHST- 2005/07/05 09:00 [entrez]
AID - 00005537-200507000-00013 [pii]
AID - 10.1097/01.MLG.0000163755.21035.8F [doi]
PST - ppublish
SO  - Laryngoscope. 2005 Jul;115(7):1212-8. doi: 10.1097/01.MLG.0000163755.21035.8F.