PMID- 15996866
OWN - NLM
STAT- MEDLINE
DCOM- 20060714
LR  - 20131121
IS  - 0968-0004 (Print)
IS  - 0968-0004 (Linking)
VI  - 30
IP  - 8
DP  - 2005 Aug
TI  - HIF-1alpha and p53: the ODD couple?
PG  - 426-9
AB  - Tumor hypoxia activates hypoxia-inducible factor-1 (HIF-1) and induces the 
      accumulation of the tumor suppressor p53. HIF-1 signaling stimulates angiogenesis 
      and mediates cellular adaptation to hypoxia, whereas p53 promotes hypoxia-induced 
      apoptosis. A recent article provides in vitro biophysical evidence supporting a 
      direct interaction between p53 and the oxygen-dependent degradation domain of the 
      HIF-1alpha subunit. The article identifies potential structural parameters 
      required for this interaction and suggests an alternative mechanism by which p53 
      might impact tumor response to therapy.
FAU - Fels, Diane R
AU  - Fels DR
AD  - Department of Cancer Biology, Wake Forest University School of Medicine, 
      Winston-Salem, NC 27157, USA.
FAU - Koumenis, Constantinos
AU  - Koumenis C
LA  - eng
PT  - Journal Article
PL  - England
TA  - Trends Biochem Sci
JT  - Trends in biochemical sciences
JID - 7610674
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - S88TT14065 (Oxygen)
SB  - IM
EIN - Trends Biochem Sci. 2005 Oct;30(10):535
MH  - Animals
MH  - Cell Hypoxia/physiology
MH  - Humans
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
MH  - Oxygen/*metabolism
MH  - Protein Binding
MH  - Signal Transduction
MH  - Tumor Suppressor Protein p53/*metabolism
EDAT- 2005/07/06 09:00
MHDA- 2006/07/15 09:00
CRDT- 2005/07/06 09:00
PHST- 2005/02/11 00:00 [received]
PHST- 2005/05/26 00:00 [revised]
PHST- 2005/06/22 00:00 [accepted]
PHST- 2005/07/06 09:00 [pubmed]
PHST- 2006/07/15 09:00 [medline]
PHST- 2005/07/06 09:00 [entrez]
AID - S0968-0004(05)00188-X [pii]
AID - 10.1016/j.tibs.2005.06.009 [doi]
PST - ppublish
SO  - Trends Biochem Sci. 2005 Aug;30(8):426-9. doi: 10.1016/j.tibs.2005.06.009.