PMID- 15997106
OWN - NLM
STAT- MEDLINE
DCOM- 20051019
LR  - 20190720
IS  - 0918-6158 (Print)
IS  - 0918-6158 (Linking)
VI  - 28
IP  - 7
DP  - 2005 Jul
TI  - Effect of methanol extract of Sorbus cortex in a rat model of L-NAME-induced 
      atherosclerosis.
PG  - 1239-43
AB  - Chronic inhibition of nitric oxide (NO) synthesis by administration of high dose 
      of N(G)-nitro-L-arginine methylester (L-NAME) induces vascular inflammation and 
      subsequent atherosclerosis. We aimed to investigate whether the methanol extract 
      of Sorbus commixta cortex (MSC) is able to prevent inflammatory process in a rat 
      model of L-NAME-induced atherosclerosis. Chronic treatment with low or high doses 
      of MSC prevented the L-NAME-induced increase in monocyte chemoattractant 
      protein-1 (MCP-1) and nuclear factor-kappaB (NF-kappaB) p65 expressions as well 
      as adhesion molecules including intercellular adhesion molecule-1 (ICAM-1) and 
      vascular cell adhesion molecule-1 (VCAM-1), and E-selectin in aorta. In addition, 
      increased endothelin-1 (ET-1) and angiotensin converting enzyme (ACE) expressions 
      and decreased endothelial cell NO synthase (ecNOS) expression in aorta from 
      L-NAME treated group was reversed by treatment with MSC. From the histological 
      examination, aortic segment from the L-NAME-treated rats revealed a thickening of 
      intima and media, which was ameliorated by treatment with MSC. In conclusion, our 
      results indicate that MSC can prevent atherosclerosis by inhibiting vascular 
      over-expressions of vasoactive materials, pro-inflammatory transcription factor, 
      and adhesion molecules and by augmenting ecNOS in chronic L-NAME-treated rat 
      model.
FAU - Sohn, Eun Jin
AU  - Sohn EJ
AD  - Professional Graduate School of Oriental Medicine and Medicinal Resources 
      Research Institute (MeRRI), Wonkwang University, Jeonbuk, Republic of Korea.
FAU - Kang, Dae Gill
AU  - Kang DG
FAU - Choi, Deok Ho
AU  - Choi DH
FAU - Lee, An Sook
AU  - Lee AS
FAU - Mun, Yeon Ja
AU  - Mun YJ
FAU - Woo, Won Hong
AU  - Woo WH
FAU - Kim, Jin Sook
AU  - Kim JS
FAU - Lee, Ho Sub
AU  - Lee HS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Chemokine CCL2)
RN  - 0 (DNA Primers)
RN  - 0 (Endothelin-1)
RN  - 0 (NF-kappa B)
RN  - 0 (Plant Extracts)
RN  - 0 (RNA, Messenger)
RN  - 0 (Transcription Factor RelA)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase)
RN  - EC 1.14.13.39 (Nitric Oxide Synthase Type III)
RN  - EC 1.14.13.39 (Nos3 protein, rat)
RN  - V55S2QJN2X (NG-Nitroarginine Methyl Ester)
RN  - Y4S76JWI15 (Methanol)
SB  - IM
MH  - Animals
MH  - Arteriosclerosis/*chemically induced/enzymology/metabolism
MH  - Base Sequence
MH  - Cell Adhesion Molecules/metabolism
MH  - Chemokine CCL2/metabolism
MH  - DNA Primers
MH  - Endothelin-1/genetics
MH  - Methanol/*chemistry
MH  - NF-kappa B/metabolism
MH  - NG-Nitroarginine Methyl Ester/*toxicity
MH  - Nitric Oxide Synthase/metabolism
MH  - Nitric Oxide Synthase Type III
MH  - Plant Extracts/*pharmacology
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sorbus/*chemistry
MH  - Transcription Factor RelA
EDAT- 2005/07/06 09:00
MHDA- 2005/10/20 09:00
CRDT- 2005/07/06 09:00
PHST- 2005/07/06 09:00 [pubmed]
PHST- 2005/10/20 09:00 [medline]
PHST- 2005/07/06 09:00 [entrez]
AID - JST.JSTAGE/bpb/28.1239 [pii]
AID - 10.1248/bpb.28.1239 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2005 Jul;28(7):1239-43. doi: 10.1248/bpb.28.1239.