PMID- 15997241
OWN - NLM
STAT- MEDLINE
DCOM- 20060609
LR  - 20221207
IS  - 0307-0565 (Print)
IS  - 0307-0565 (Linking)
VI  - 29
IP  - 12
DP  - 2005 Dec
TI  - Association study between chromosome 10q26.11 and obesity among Swedish men.
PG  - 1422-8
AB  - OBJECTIVE: Proximal chromosome 10q26 was recently linked to waist/hip ratio in 
      European and African-American families. The objective was to investigate whether 
      genomic variation in chromosome 10q26.11 reflects variation in obesity-related 
      clinical parameters in a Swedish population. DESIGN: Genetic association study of 
      single-nucleotide polymorphisms (SNPs) in chromosome 10q26.11 and obesity-related 
      clinical parameters was performed. Obesity was defined as body mass index (BMI) > 
      or = 30 kg/m2. SUBJECTS: Swedish Caucasians comprising 276 obese and 480 nonobese 
      men, 313 obese and 494 nonobese women, 177 obese and 163 nonobese patients with 
      type 2 diabetes mellitus (T2DM), and 106 obese and 201 nonobese subjects with 
      impaired glucose tolerance (IGT) patients. MEASUREMENTS: Genotypes of 11 SNPs at 
      chromosome 10q26.11, and various obesity-related clinical parameters. RESULTS: 
      Homozygosity of a common haplotype constructed by three SNPs, rs2185937, rs1797 
      and hCV1402327, covering an interval of 2.7 kb, was suggested to confer an 
      increased risk for obesity of 1.5 among men (P = 0.043). The C allele frequency 
      and homozygous genotype frequency of the rs1797 tended to be higher among obese 
      compared to among nonobese men (P = 0.017 and 0.020, respectively). The 
      distribution of BMI and diastolic blood pressure was higher among those with the 
      C/C genotype (P = 0.022 and 0.0061, respectively). The obese and the nonobese 
      groups were homogeneous over BMI subgroups with regard to rs1797 risk genotype 
      distribution. There was no tendency for association between rs1797 and obesity 
      among neither women nor T2DM nor IGT patients. CONCLUSION: We show support for 
      association between proximal chromosome 10q26.11 and obesity among Swedish men 
      but not women through the analysis of a haplotype encompassing 2.7 kb.
FAU - Lavebratt, C
AU  - Lavebratt C
AD  - Department of Molecular Medicine, Karolinska Institutet, CMM, Karolinska 
      Hospital, Stockholm, Sweden. catharina.lavebratt@cmm.ki.se
FAU - Sengul, S
AU  - Sengul S
FAU - Gu, H F
AU  - Gu HF
FAU - Persson, B
AU  - Persson B
FAU - Nordfors, L
AU  - Nordfors L
FAU - Ostenson, C-G
AU  - Ostenson CG
FAU - Efendic, S
AU  - Efendic S
FAU - Arner, P
AU  - Arner P
FAU - Hoffstedt, J
AU  - Hoffstedt J
FAU - Schalling, M
AU  - Schalling M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Obes (Lond)
JT  - International journal of obesity (2005)
JID - 101256108
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Chromosomes, Human, Pair 10/*genetics
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - Homozygote
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Obesity/*genetics
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Sweden
MH  - White People/genetics
EDAT- 2005/07/06 09:00
MHDA- 2006/06/10 09:00
CRDT- 2005/07/06 09:00
PHST- 2005/07/06 09:00 [pubmed]
PHST- 2006/06/10 09:00 [medline]
PHST- 2005/07/06 09:00 [entrez]
AID - 0803033 [pii]
AID - 10.1038/sj.ijo.0803033 [doi]
PST - ppublish
SO  - Int J Obes (Lond). 2005 Dec;29(12):1422-8. doi: 10.1038/sj.ijo.0803033.