PMID- 15998927
OWN - NLM
STAT- MEDLINE
DCOM- 20051115
LR  - 20190101
IS  - 1079-2082 (Print)
IS  - 1079-2082 (Linking)
VI  - 62
IP  - 14
DP  - 2005 Jul 15
TI  - Dietary supplement-related adverse events reported to the California Poison 
      Control System.
PG  - 1476-82
AB  - PURPOSE: Dietary supplement (DS)-related adverse events (AEs) reported to the 
      California Poison Control System (CPCS) were studied. METHODS: The CPCS database 
      was used to search for all telephone calls from consumers concerning DS-related 
      AEs received during the six-month period between April and September 2002. The 
      calls were characterized according to the substance involved, the caller's age 
      (adult or pediatric), and the type of ingestion (accidental or intentional). Each 
      exposure in which symptoms were reported was categorized as involving an AE. Each 
      AE was assessed for severity and causality. RESULTS: Data on a total of 1183 
      telephone calls were retrieved, of which 828 calls (70%) met the study's 
      inclusion criteria. DS exposure occurred in 389 adults (47%) and 438 children 
      (53%). DS ingestion was accidental in 360 patients (43%) and intentional in 467 
      patients (56%). Exposure resulted in an AE in 480 patients (58%). AEs were 
      reported in 353 patients (74%) who ingested products containing ephedra; other 
      exposures frequently involved zinc, kava, creatine, and valerian. AEs were 
      classified as moderate in 198 patients (41%) who ingested a DS and as severe in 
      40 patients (8%). One patient had a fatal reaction. Among the 480 AEs in 
      DS-exposed consumers, the DS was classified as the definite cause of 1 AE (<1%) 
      and a probable cause of 237 (49.4%). The most frequently reported AE symptoms 
      were increased heart rate (45%), agitation (30%), vomiting (30%), and nausea 
      (15%). CONCLUSION: A majority of DS-related AEs reported by consumers to CPCS 
      involved ephedra-containing products.
FAU - Dennehy, Cathi E
AU  - Dennehy CE
AD  - School of Pharmacy, University of California San Francisco (UCSF), 94143, USA.
FAU - Tsourounis, Candy
AU  - Tsourounis C
FAU - Horn, Angela J
AU  - Horn AJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - Am J Health Syst Pharm
JT  - American journal of health-system pharmacy : AJHP : official journal of the 
      American Society of Health-System Pharmacists
JID - 9503023
RN  - 0 (Drugs, Chinese Herbal)
SB  - IM
MH  - Adult
MH  - *Adverse Drug Reaction Reporting Systems
MH  - California/epidemiology
MH  - Child
MH  - Data Collection/methods
MH  - Dietary Supplements/*adverse effects/classification/poisoning
MH  - Drugs, Chinese Herbal/adverse effects/poisoning
MH  - Ephedra
MH  - Female
MH  - Humans
MH  - Male
MH  - Plants, Medicinal
MH  - *Poison Control Centers
MH  - Retrospective Studies
EDAT- 2005/07/07 09:00
MHDA- 2005/11/16 09:00
CRDT- 2005/07/07 09:00
PHST- 2005/07/07 09:00 [pubmed]
PHST- 2005/11/16 09:00 [medline]
PHST- 2005/07/07 09:00 [entrez]
AID - 62/14/1476 [pii]
AID - 10.2146/ajhp040412 [doi]
PST - ppublish
SO  - Am J Health Syst Pharm. 2005 Jul 15;62(14):1476-82. doi: 10.2146/ajhp040412.