PMID- 15999549
OWN - NLM
STAT- MEDLINE
DCOM- 20050830
LR  - 20191210
IS  - 0258-851X (Print)
IS  - 0258-851X (Linking)
VI  - 19
IP  - 4
DP  - 2005 Jul-Aug
TI  - Comparison of the effect of 99mTc-DPD and 99mTc-MDP on experimentally-induced 
      osteoarthritis in the stifle joint of the dog.
PG  - 781-5
AB  - This study was designed to evaluate the effect of 99mTechnetium-dicarboxypropane 
      diphosphonate (99mTc-DPD) and 99mTechnetium-methylene diphosphonate (99mTc-MDP) 
      on bone scan image quality and time in dogs with osteoarthritis. The left cranial 
      cruciate ligament (CrCL) in ten healthy adult Beagle dogs was transected under 
      general anesthesia. The dogs were assigned to 99mTc-DPD-injected or 
      99mTc-MDP-injected groups. Stifle joint scintigraphy was performed after 
      intravenous injection of 10 mCi 99mTc-DPD or 99mTe-MDP. Scintigraphy was 
      conducted before CrCL transection and 2, 4, 6, 8, 10 and 12 weeks after the 
      procedure. There were no significant differences in density, sensitivity and 
      pathological foci between the 99mTc-DPD and 99mTc-MDP groups of 
      experimentally-transected CrCL dogs. A comparison of the images obtained with 
      Pinhole type and low energy general purpose type collimators of the stifle joint 
      of normal dogs and after CrCL transaction revealed no significant differences in 
      bone radioactivity. Scintigraphs were obtained 3 h after 99mTc-MDP and 2 h after 
      99mTc-DPD injection. In conclusion, application of 99mTc-DPD and 99mTc-MDP in 
      experimentally-induced osteoarthritis of the stifle joint in dogs results in 
      similar effects on radioactive uptake ratio and image quality. 99mTc-DPD is more 
      efficient than 99mTc-MDP in reducing the overall time of scintigraphy.
FAU - Lee, Jae Yeong
AU  - Lee JY
AD  - College of Veterinary Medicine, Chungbuk National University, Republic of Korea.
FAU - Lee, Won Guk
AU  - Lee WG
FAU - Kim, Joong-Hyun
AU  - Kim JH
FAU - Kang, Seong Soo
AU  - Kang SS
FAU - Bae, Chun Sik
AU  - Bae CS
FAU - Koong, Sung-Soo
AU  - Koong SS
FAU - Choi, Seok Hwa
AU  - Choi SH
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - In Vivo
JT  - In vivo (Athens, Greece)
JID - 8806809
RN  - 0 (Diphosphonates)
RN  - 0 (Organotechnetium Compounds)
RN  - 0 (technetium Tc 99m 1,1-diphosphonopropane-2,3-dicarboxylic acid)
RN  - X89XV46R07 (Technetium Tc 99m Medronate)
SB  - IM
MH  - Animals
MH  - Anterior Cruciate Ligament/diagnostic imaging/surgery
MH  - *Diphosphonates
MH  - Disease Models, Animal
MH  - Dogs
MH  - *Organotechnetium Compounds
MH  - Osteoarthritis/*diagnostic imaging/etiology/pathology
MH  - Radionuclide Imaging
MH  - Stifle/*diagnostic imaging/pathology
MH  - *Technetium Tc 99m Medronate
EDAT- 2005/07/08 09:00
MHDA- 2005/09/01 09:00
CRDT- 2005/07/08 09:00
PHST- 2005/07/08 09:00 [pubmed]
PHST- 2005/09/01 09:00 [medline]
PHST- 2005/07/08 09:00 [entrez]
PST - ppublish
SO  - In Vivo. 2005 Jul-Aug;19(4):781-5.