PMID- 16001122
OWN - NLM
STAT- MEDLINE
DCOM- 20060302
LR  - 20181113
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 181
IP  - 4
DP  - 2005 Oct
TI  - Role of 5-HT2A and 5-HT2C/B receptors in the acute effects of 
      3,4-methylenedioxymethamphetamine (MDMA) on striatal single-unit activity and 
      locomotion in freely moving rats.
PG  - 676-87
AB  - RATIONALE: Like amphetamine, a locomotor-activating dose of 
      3,4-methylenedioxymethamphetamine (MDMA) predominantly excites striatal 
      single-unit activity in freely moving rats. Although both D1- and D2-like 
      dopamine (DA) receptors play important roles in this effect, MDMA, unlike 
      amphetamine, strongly increases both DA and serotonin (5-HT) transmission. 
      OBJECTIVES: This study was conducted to investigate the 5-HT receptor mechanisms 
      underlying the striatal effects of MDMA. METHODS: We recorded the activity of 
      >200 single units in the striatum of awake, unrestrained rats in response to 
      acute MDMA administration (5 mg/kg) combined with the selective blockade of 
      either 5-HT2A or 5-HT2C/B receptors. RESULTS: Prior administration of SR-46349B 
      (a 5-HT2A antagonist 0.5 mg/kg) blocked nearly all MDMA-induced striatal 
      excitations, which paralleled its significant attenuation of MDMA-induced 
      locomotor activation. Conversely, prior administration of SB-206553 (a 5-HT2C/B 
      antagonist 2.0 mg/kg) had no effect on the amount of MDMA-induced locomotor 
      activation or the distribution of single-unit responses to MDMA. However, a 
      coefficient-of-variation analysis indicated significantly less variability in the 
      magnitude of both MDMA-induced neuronal excitations and inhibitions in rats that 
      were pretreated with SB-206553 compared to vehicle. Analysis of concurrent 
      single-unit activity and behavior confirmed that MDMA-induced striatal activation 
      was not merely due to behavioral feedback, indicating a primary action of MDMA. 
      CONCLUSION: These results support and extend our previous findings by showing 
      that 5-HT2A and 5-HT2C/B receptors differentially regulate the expression of 
      MDMA-induced behavioral and striatal neuronal responses, either directly or 
      through the modulation of DA transmission.
FAU - Ball, Kevin T
AU  - Ball KT
AD  - Department of Psychology and Program in Neural Science, Indiana University, 1101 
      East 10th Street, Bloomington, IN 47405, USA.
FAU - Rebec, George V
AU  - Rebec GV
LA  - eng
GR  - DA 02451/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20050929
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Fluorobenzenes)
RN  - 0 (Indoles)
RN  - 0 (Phenols)
RN  - 0 (Pyridines)
RN  - 0 (Receptor, Serotonin, 5-HT2A)
RN  - 0 (Receptor, Serotonin, 5-HT2B)
RN  - 0 (Receptor, Serotonin, 5-HT2C)
RN  - 0 (Serotonin Antagonists)
RN  - 0 (Serotonin Receptor Agonists)
RN  - 130580-02-8 (SR 46349B)
RN  - AL4387525T (SB 206553)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Amphetamine-Related Disorders/physiopathology
MH  - Animals
MH  - Corpus Striatum/*drug effects
MH  - Dopamine/metabolism
MH  - Electroencephalography/*drug effects
MH  - Fluorobenzenes/pharmacology
MH  - Indoles/pharmacology
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Neurons/drug effects
MH  - Phenols/pharmacology
MH  - Pyridines/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, Serotonin, 5-HT2A/*drug effects
MH  - Receptor, Serotonin, 5-HT2B/*drug effects
MH  - Receptor, Serotonin, 5-HT2C/*drug effects
MH  - Serotonin Antagonists/pharmacology
MH  - Serotonin Receptor Agonists/pharmacology
EDAT- 2005/07/08 09:00
MHDA- 2006/03/03 09:00
CRDT- 2005/07/08 09:00
PHST- 2004/09/23 00:00 [received]
PHST- 2005/04/19 00:00 [accepted]
PHST- 2005/07/08 09:00 [pubmed]
PHST- 2006/03/03 09:00 [medline]
PHST- 2005/07/08 09:00 [entrez]
AID - 10.1007/s00213-005-0038-z [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2005 Oct;181(4):676-87. doi: 
      10.1007/s00213-005-0038-z. Epub 2005 Sep 29.