PMID- 16001329
OWN - NLM
STAT- MEDLINE
DCOM- 20050929
LR  - 20090219
IS  - 0018-5043 (Print)
IS  - 0018-5043 (Linking)
VI  - 37
IP  - 6
DP  - 2005 Jun
TI  - Menin molecular interactions: insights into normal functions and tumorigenesis.
PG  - 369-74
AB  - Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disease 
      predisposed by heterozygous germline mutations in the MEN1 tumor suppressor gene. 
      Biallelic loss of MEN1 resulting from small mutation and/or loss of 
      heterozygosity occurs in a large tissue spectrum of MEN1 tumors or non-hereditary 
      tumors. Mouse models of MEN1 underexpression or overexpression have also 
      supported the tumor-suppressor effect of the MEN1 gene. Menin, the 610-amino-acid 
      protein encoded by MEN1, is expressed ubiquitously and found predominantly in the 
      nucleus. Sequence analyses do not reveal motifs of known function other than two 
      nuclear localization sequences. Menin has been found to partner in vitro with a 
      variety of proteins that comprise transcription factors, DNA processing factors, 
      DNA repair proteins, and cytoskeletal proteins. The diverse functions of menin 
      interactors suggest roles for menin in multiple biological pathways. Inactivation 
      of menin switches its JunD partner from a downstream action of growth suppression 
      to growth promotion. This is a plausible mechanism for menin tumorigenesis.
FAU - Agarwal, S K
AU  - Agarwal SK
AD  - National Institute of Diabetes and Digestive and Kidney Diseases/NIH, 9000 
      Rockville Pike, Bethesda, MD 20892-1802, USA. SunitaA@intra.niddk.nih.gov
FAU - Kennedy, P A
AU  - Kennedy PA
FAU - Scacheri, P C
AU  - Scacheri PC
FAU - Novotny, E A
AU  - Novotny EA
FAU - Hickman, A B
AU  - Hickman AB
FAU - Cerrato, A
AU  - Cerrato A
FAU - Rice, T S
AU  - Rice TS
FAU - Moore, J B
AU  - Moore JB
FAU - Rao, S
AU  - Rao S
FAU - Ji, Y
AU  - Ji Y
FAU - Mateo, C
AU  - Mateo C
FAU - Libutti, S K
AU  - Libutti SK
FAU - Oliver, B
AU  - Oliver B
FAU - Chandrasekharappa, S C
AU  - Chandrasekharappa SC
FAU - Burns, A L
AU  - Burns AL
FAU - Collins, F S
AU  - Collins FS
FAU - Spiegel, A M
AU  - Spiegel AM
FAU - Marx, S J
AU  - Marx SJ
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Horm Metab Res
JT  - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et 
      metabolisme
JID - 0177722
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Transcription Factors)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - Cell Nucleus/metabolism
MH  - Cytoskeletal Proteins/metabolism
MH  - DNA/metabolism
MH  - *Gene Expression Regulation, Neoplastic/genetics
MH  - Humans
MH  - Multiple Endocrine Neoplasia Type 1/genetics/*metabolism
MH  - Protein Binding
MH  - Proto-Oncogene Proteins/genetics/*metabolism
MH  - Transcription Factors/metabolism
MH  - Transcription, Genetic
RF  - 57
EDAT- 2005/07/08 09:00
MHDA- 2005/09/30 09:00
CRDT- 2005/07/08 09:00
PHST- 2005/07/08 09:00 [pubmed]
PHST- 2005/09/30 09:00 [medline]
PHST- 2005/07/08 09:00 [entrez]
AID - 10.1055/s-2005-870139 [doi]
PST - ppublish
SO  - Horm Metab Res. 2005 Jun;37(6):369-74. doi: 10.1055/s-2005-870139.