PMID- 16002063
OWN - NLM
STAT- MEDLINE
DCOM- 20051214
LR  - 20221207
IS  - 0009-8981 (Print)
IS  - 0009-8981 (Linking)
VI  - 360
IP  - 1-2
DP  - 2005 Oct
TI  - N-terminal-pro-B-type natriuretic peptide (NT-proBNP): reference range for 
      Chinese apparently healthy people and clinical performance in Chinese elderly 
      patients with heart failure.
PG  - 122-7
AB  - BACKGROUND: N-terminal-pro-B-type natriuretic peptide (NT-proBNP) has been found 
      to be a useful marker for the diagnosis of heart failure (HF) and left 
      ventricular systolic dysfunction. We established a reference range for Chinese 
      apparently healthy people based on age and gender and evaluated the clinical 
      performance of NT-proBNP in the diagnosis of asymptomatic and symptomatic HF. 
      METHODS: A group of 442 apparently healthy subjects were enrolled for reference 
      range study. For the clinical performance study, serum NT-proBNP and clinical 
      data were analyzed in 111 elderly patients with HF and 60 normal elderly 
      controls. Serum NT-proBNP was measured by the Roche Elecsys 2010 immunoassay 
      analyzer. RESULTS: NT-proBNP reference range in Chinese people based on age and 
      gender was <83.72 ng/l for men and <131.6 ng/l for women aged <or=60 years, and 
      <158.17 ng/l for men and <205.54 ng/l for women aged >60 years, which were lower 
      than those for western countries. NT-proBNP had a close correlation with New York 
      Heart Association (NYHA) classification (r=0.818) and LVEF (r=-0.636). The ROC 
      curve analysis revealed an AUC of 0.921 for the diagnosis of HF, 0.840 for 
      asymptomatic HF (NYHA I) and 0.951 for symptomatic HF (NYHA II-IV). The optimal 
      cutoff values for detecting HF, asymptomatic HF and symptomatic HF were 102.2, 
      102.2, and 204.8 ng/l, respectively. NT-proBNP had high positive predictive value 
      (PPV) for the diagnosis of HF (96.8%), asymptomatic HF (90.3%) and symptomatic HF 
      (90.9%), but low negative predictive value (NPV) for diagnosing HF and 
      asymptomatic HF (74.0% and 78.1%, respectively) except symptomatic HF (93.3%). 
      CONCLUSIONS: Chinese people have lower reference range of serum NT-proBNP. 
      NT-proBNP assay has a good clinical performance for the diagnosis of symptomatic 
      HF but is not suitable as a screening test for HF.
FAU - Shi, Xiaomin
AU  - Shi X
AD  - Department of Medicine Laboratory, Peking University First Hospital, 8 Xi Shi Ku 
      Street, Beijing 100034, PR China.
FAU - Xu, Guobing
AU  - Xu G
FAU - Xia, Tiean
AU  - Xia T
FAU - Song, Yixin
AU  - Song Y
FAU - Lin, Qing
AU  - Lin Q
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People
MH  - Case-Control Studies
MH  - Female
MH  - Heart Failure/*diagnosis
MH  - Humans
MH  - Immunoassay
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*blood/*standards
MH  - Peptide Fragments/*blood/*standards
MH  - Predictive Value of Tests
MH  - ROC Curve
MH  - Reference Values
MH  - Sex Factors
MH  - Stroke Volume
EDAT- 2005/07/09 09:00
MHDA- 2005/12/15 09:00
CRDT- 2005/07/09 09:00
PHST- 2005/02/22 00:00 [received]
PHST- 2005/04/08 00:00 [revised]
PHST- 2005/04/10 00:00 [accepted]
PHST- 2005/07/09 09:00 [pubmed]
PHST- 2005/12/15 09:00 [medline]
PHST- 2005/07/09 09:00 [entrez]
AID - S0009-8981(05)00261-5 [pii]
AID - 10.1016/j.cccn.2005.04.033 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2005 Oct;360(1-2):122-7. doi: 10.1016/j.cccn.2005.04.033.