PMID- 16003246
OWN - NLM
STAT- MEDLINE
DCOM- 20050926
LR  - 20231213
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 80
IP  - 1
DP  - 2005 Jul 15
TI  - Association of HLA-E polymorphism with severe bacterial infection and early 
      transplant-related mortality in matched unrelated bone marrow transplantation.
PG  - 140-4
AB  - Despite prophylactic measures, susceptibility to severe infections in patients 
      who had undergone bone marrow transplantation (BMT) is quite variable. To 
      evaluate the potential role of human leukocyte antigen (HLA)-E polymorphism on 
      the incidence of early infections, we analyzed 77 unrelated-donor (UD) BMT pairs 
      identically matched for classical HLA class I and class II alleles. Multivariate 
      analysis taking into account the patient-, donor- and transplant-related factors 
      showed that bacterial infections and transplant-related mortality (TRM) at day 
      180 were high when the donor genotype was HLA-E*0101/E*0101 (hazard ratio 
      [HR]=2.20; P=0.03 and HR=2.12, P=0.048, respectively), suggesting that homozygous 
      state for HLA-E*0101 allele is a risk factor for early severe bacterial 
      infections and TRM in UD-BMT.
FAU - Tamouza, Ryad
AU  - Tamouza R
AD  - Laboratoire d'Immunologie et d'Histocompatibilite AP-HP, IUH, and INSERM U662, 
      Hopital Saint-Louis, Paris, France. tamouza@histo.chu-stlouis.fr
FAU - Rocha, Vanderson
AU  - Rocha V
FAU - Busson, Marc
AU  - Busson M
FAU - Fortier, Catherine
AU  - Fortier C
FAU - El Sherbini, Sherif M
AU  - El Sherbini SM
FAU - Esperou, Helene
AU  - Esperou H
FAU - Filion, Alain
AU  - Filion A
FAU - Socie, Gerard
AU  - Socie G
FAU - Dulphy, Nicolas
AU  - Dulphy N
FAU - Krishnamoorthy, Rajagopal
AU  - Krishnamoorthy R
FAU - Toubert, Antoine
AU  - Toubert A
FAU - Gluckman, Eliane
AU  - Gluckman E
FAU - Charron, Dominique
AU  - Charron D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
CIN - Transplantation. 2009 Nov 27;88(10):1227-8. PMID: 19935378
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Bacterial Infections/*epidemiology
MH  - Bone Marrow Diseases/surgery
MH  - Bone Marrow Transplantation/*pathology
MH  - Child
MH  - Child, Preschool
MH  - Cytomegalovirus Infections/epidemiology
MH  - Female
MH  - HLA Antigens/*genetics
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/surgery
MH  - *Polymorphism, Genetic
MH  - Postoperative Complications/*epidemiology
MH  - Tissue Donors
MH  - HLA-E Antigens
EDAT- 2005/07/09 09:00
MHDA- 2005/09/27 09:00
CRDT- 2005/07/09 09:00
PHST- 2005/07/09 09:00 [pubmed]
PHST- 2005/09/27 09:00 [medline]
PHST- 2005/07/09 09:00 [entrez]
AID - 00007890-200507150-00024 [pii]
AID - 10.1097/01.tp.0000158711.37550.a0 [doi]
PST - ppublish
SO  - Transplantation. 2005 Jul 15;80(1):140-4. doi: 10.1097/01.tp.0000158711.37550.a0.