PMID- 16003466
OWN - NLM
STAT- MEDLINE
DCOM- 20051019
LR  - 20181113
IS  - 0093-7711 (Print)
IS  - 0093-7711 (Linking)
VI  - 57
IP  - 6
DP  - 2005 Jul
TI  - Classification of A1- and A24-supertype molecules by analysis of their 
      MHC-peptide binding repertoires.
PG  - 393-408
AB  - At the functional level, the majority of human leukocyte antigen (HLA) class I 
      MHC variants can be classified into about ten different major groups, or 
      supertypes, characterized by overlapping peptide binding motifs and repertoires. 
      Previous studies have detailed the peptide binding specificity of the HLA A2, A3, 
      B7, and B44 supertypes, and predicted, on the basis of MHC pocket structures, 
      known motifs, or the sequence of T cell epitopes, the existence of the HLA A1 and 
      A24 supertypes. Direct experimental validation of the A1 and A24 supertypes, 
      however, has been lacking. In the current study, the peptide-binding repertoires 
      and main anchor specificities of several common HLA A molecules (A*0101, A*2301, 
      A*2402, A*2601, A*2902, and A*3002) predicted to be members of the A1 or A24 
      supertypes were analyzed and defined using single amino acid substituted peptides 
      and a large peptide library. Based on the present findings, the A1 supertype 
      includes A*0101, A*2601, A*2902, and A*3002, whereas the A24 supertype includes 
      A*2301 and A*2402. Interestingly, A*2902 is associated with a motif and peptide 
      binding repertoire that overlaps significantly with those of all of the A1- and 
      A24-supertype molecules studied, representing-to our knowledge-the first report 
      of significant cross-reactivity among molecules belonging to different 
      supertypes.
FAU - Sidney, John
AU  - Sidney J
AD  - La Jolla Institute for Allergy and Immunology, 3030 Bunker Hill St., Ste. 326, 
      San Diego, CA, 92109, USA. alex@liai.org
FAU - Southwood, Scott
AU  - Southwood S
FAU - Sette, Alessandro
AU  - Sette A
LA  - eng
GR  - N01-AI-40023/AI/NIAID NIH HHS/United States
GR  - N01-AI-40024/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20050708
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-A1 Antigen)
RN  - 0 (HLA-A24 Antigen)
RN  - 0 (Peptides)
SB  - IM
MH  - Amino Acid Motifs
MH  - Amino Acid Sequence
MH  - Cross Reactions
MH  - HLA-A Antigens/*chemistry/*classification/metabolism
MH  - HLA-A1 Antigen/*chemistry/*classification/metabolism
MH  - HLA-A24 Antigen
MH  - Humans
MH  - Molecular Sequence Data
MH  - Peptides/chemistry/metabolism
EDAT- 2005/07/09 09:00
MHDA- 2005/10/20 09:00
CRDT- 2005/07/09 09:00
PHST- 2005/02/04 00:00 [received]
PHST- 2005/05/12 00:00 [accepted]
PHST- 2005/07/09 09:00 [pubmed]
PHST- 2005/10/20 09:00 [medline]
PHST- 2005/07/09 09:00 [entrez]
AID - 10.1007/s00251-005-0004-2 [doi]
PST - ppublish
SO  - Immunogenetics. 2005 Jul;57(6):393-408. doi: 10.1007/s00251-005-0004-2. Epub 2005 
      Jul 8.