PMID- 16003734
OWN - NLM
STAT- MEDLINE
DCOM- 20060612
LR  - 20090112
IS  - 1545-5009 (Print)
IS  - 1545-5009 (Linking)
VI  - 46
IP  - 7
DP  - 2006 Jun
TI  - Benign pineal cysts in children with bilateral retinoblastoma: a new variant of 
      trilateral retinoblastoma?
PG  - 755-61
AB  - PURPOSE: Patients with hereditary retinoblastoma (Rb) develop in 4%-8% a 
      malignant midline tumor called trilateral Rb (TRb). We report in this study on 
      benign pineal cysts observed in patients investigated for TRb. PATIENTS AND 
      METHODS: Between September 1990 and December 2001, 172 patients were screened for 
      TRb. Ninty-five had bilateral, 77 unilateral disease. The median age at diagnosis 
      of Rb was 7 months (range 1-26). Treatment included enucleation, local treatment 
      with cryotherapy or photocoagulation, first-line chemotherapy (CT), 
      thermo-chemotherapy (TCT), Ruthenium plaque, and, rarely, external beam radiation 
      (EBR). RESULTS: TRb was found in 5/95 patients (5.3%) with bilateral disease. 
      Interestingly, five other patients (5.3%) presented a pineal cyst on magnetic 
      resonance imaging (MRI). No cysts were recorded in the 77 patients with 
      unilateral disease. This difference was statistically significant (P < 0.05). The 
      median age at diagnosis of the pineal cyst was 26 months (range 16-80), much 
      younger than reported in literature for healthy children. Four of five patients 
      with TRb died of the disease, while all the patients with pineal cysts remained 
      stable and asymptomatic during a median follow-up of 41 months (range 37-54). 
      CONCLUSIONS: This report describes benign cystic lesions of the pineal gland in 
      patients with hereditary Rb, suggesting a benign variant of TRb. Underlying 
      possible pathogenetic mechanisms are discussed.
CI  - (c) 2005 Wiley-Liss, Inc.
FAU - Beck Popovic, Maja
AU  - Beck Popovic M
AD  - Pediatric Hematology-Oncology Unit, University Hospital, Lausanne, Switzerland. 
      Maja.Beck-Popovic@hospvd.ch
FAU - Balmer, Aubin
AU  - Balmer A
FAU - Maeder, Philippe
AU  - Maeder P
FAU - Braganca, Teresa
AU  - Braganca T
FAU - Munier, Francis L
AU  - Munier FL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pediatr Blood Cancer
JT  - Pediatric blood & cancer
JID - 101186624
SB  - IM
MH  - Brain Neoplasms/etiology/pathology
MH  - Central Nervous System Cysts/epidemiology/*etiology/*pathology
MH  - Child, Preschool
MH  - Humans
MH  - Infant
MH  - Magnetic Resonance Imaging
MH  - *Pineal Gland
MH  - Pinealoma/etiology/pathology
MH  - Prognosis
MH  - Retinal Neoplasms/*complications
MH  - Retinoblastoma/*complications
MH  - Switzerland/epidemiology
MH  - Tomography, X-Ray Computed
EDAT- 2005/07/09 09:00
MHDA- 2006/06/13 09:00
CRDT- 2005/07/09 09:00
PHST- 2005/07/09 09:00 [pubmed]
PHST- 2006/06/13 09:00 [medline]
PHST- 2005/07/09 09:00 [entrez]
AID - 10.1002/pbc.20464 [doi]
PST - ppublish
SO  - Pediatr Blood Cancer. 2006 Jun;46(7):755-61. doi: 10.1002/pbc.20464.