PMID- 16003759
OWN - NLM
STAT- MEDLINE
DCOM- 20051213
LR  - 20240109
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 118
IP  - 1
DP  - 2006 Jan 1
TI  - Molecular mechanisms of HLA class I antigen abnormalities following viral 
      infection and transformation.
PG  - 129-38
AB  - In humans as in other animal species, CD8+ cytotoxic T lymphocytes (CTLs) play an 
      important if not the major role in controlling virus-infected and malignant cell 
      growth. The interactions between CD8+ T cells and target cells are mediated by 
      human leukocyte antigen (HLA) class I antigens loaded with viral and tumor 
      antigen-derived peptides along with costimulatory receptor/ligand stimuli. Thus, 
      to escape from CD8+ T-cell recognition and destruction, viruses and tumor cells 
      have developed strategies to inhibit the expression and/or function of HLA class 
      I antigens. In contrast, cells with downregulated MHC class I surface expression 
      can be recognized by NK cells, although NK cell-mediated lysis could be abrogated 
      by the expression of inhibiting NK cell receptors. This review discusses the 
      molecular mechanisms utilized by viruses to inhibit the formation, transport 
      and/or expression of HLA class I antigen/peptide complexes on the cell surface. 
      The knowledge about viral interference with MHC class I antigen presentation is 
      not only crucial to understand the pathogenesis of viral diseases, but 
      contributes also to the design of novel strategies to counteract the escape 
      mechanisms utilized by viruses. These investigations may eventually lead to the 
      development of effective immunotherapies to control viral infections and 
      virus-associated malignant diseases.
CI  - Copyright 2005 Wiley-Liss, Inc.
FAU - Seliger, Barbara
AU  - Seliger B
AD  - Institute of Medical Immunology, Martin Luther University, Halle, Germany. 
      barbara.seliger@medizin.uni-halle.de
FAU - Ritz, Ulrike
AU  - Ritz U
FAU - Ferrone, Soldano
AU  - Ferrone S
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (HLA Antigens)
RN  - 0 (Macromolecular Substances)
SB  - IM
MH  - CD8-Positive T-Lymphocytes/*immunology
MH  - Down-Regulation
MH  - *Genes, MHC Class I
MH  - HLA Antigens/biosynthesis/genetics/*immunology
MH  - Humans
MH  - Immunotherapy
MH  - Macromolecular Substances
MH  - Neoplasms/physiopathology/virology
MH  - Signal Transduction
MH  - Viral Interference
MH  - Virus Diseases/complications/*immunology/physiopathology
RF  - 148
EDAT- 2005/07/09 09:00
MHDA- 2005/12/15 09:00
CRDT- 2005/07/09 09:00
PHST- 2005/07/09 09:00 [pubmed]
PHST- 2005/12/15 09:00 [medline]
PHST- 2005/07/09 09:00 [entrez]
AID - 10.1002/ijc.21312 [doi]
PST - ppublish
SO  - Int J Cancer. 2006 Jan 1;118(1):129-38. doi: 10.1002/ijc.21312.