PMID- 16004514
OWN - NLM
STAT- MEDLINE
DCOM- 20050811
LR  - 20191026
IS  - 0212-7199 (Print)
IS  - 0212-7199 (Linking)
VI  - 22
IP  - 4
DP  - 2005 Apr
TI  - [Low-molecular-weight heparin for the treatment of acute pulmonary 
      thromboembolism. Comparison with unfractionated intravenous heparin].
PG  - 177-81
AB  - BACKGROUND AND OBJECTIVES: Low-molecular-weight heparins have been demonstrated 
      at least as useful as unfractionated heparin (UFH) in the treatment of venous 
      thromboembolic disease. Our aim was to know the effectivity and security of 
      subcutaneous enoxaparin in the treatment of acute pulmonary embolism. METHODS: We 
      compared the effectivity and security of two doses daily, subcutaneous injected 
      enoxaparin adjusted to body weight, and standard treatment with continuous 
      intravenous UFH, determining the rate of major bleeding, in-hospital death and 
      recurrent venous thromboembolic disease in long-term follow up. Massive pulmonary 
      thromboembolism was defined as thrombotic material seen in main pulmonary 
      arteries. RESULTS: Thirty eight patients were treated with UFH (Mean age 72 SD 9 
      years, male 58%, massive pulmonary thromboembolism 24%) and 65 patients were 
      treated with subcutaneous enoxaparin (Mean age 71 SD 12 years, male 52%, massive 
      pulmonary thromboembolism 49%). Major bleeding rate was 8% in UHF group and 3% in 
      enoxaparin group (Difference 37%, 95% Confidence interval -0.16 to 0.06, p=0.21). 
      In-hospital death rate was 8% in UHF group and 1.5% in enoxaparin group 
      (Difference 25%, 95% Confidence interval -0.17 to 0.04, p=0.11). Recurrent 
      thromboembolism rate was 44% in UFH group and 13% in enoxaparin group (Difference 
      30%, 95% Confidence interval -0.60 to -0.02, p=0.01). CONCLUSION: Our findings 
      demonstrate that treatment of acute pulmonary thromboembolism with 
      low-molecular-heparin is effective and safe, even in massive pulmonary embolism.
FAU - Alonso Martinez, J L
AU  - Alonso Martinez JL
AD  - Servicia de Medicina Interna, Hospital de Nevarra, Pamplona, Spain. 
      jalonsom@cfnavarra.es
FAU - Abinzano Guillen, M L
AU  - Abinzano Guillen ML
FAU - Solano Remirez, M
AU  - Solano Remirez M
FAU - Alvarez Frias, M T
AU  - Alvarez Frias MT
FAU - Gutierrez Dubois, J
AU  - Gutierrez Dubois J
FAU - Munuera Garcia, L
AU  - Munuera Garcia L
LA  - spa
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - Tratamiento del tromboembolismo pulmonar agudo con heparina de bajo peso 
      molecular subcutanea. Comparacion con heparina no fracionada intravenosa.
PL  - Spain
TA  - An Med Interna
JT  - Anales de medicina interna (Madrid, Spain : 1984)
JID - 9112183
RN  - 0 (Anticoagulants)
RN  - 0 (Enoxaparin)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Aged
MH  - Anticoagulants/*therapeutic use
MH  - Enoxaparin/*therapeutic use
MH  - Female
MH  - Heparin/*therapeutic use
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Embolism/*drug therapy
EDAT- 2005/07/12 09:00
MHDA- 2005/08/12 09:00
CRDT- 2005/07/12 09:00
PHST- 2005/07/12 09:00 [pubmed]
PHST- 2005/08/12 09:00 [medline]
PHST- 2005/07/12 09:00 [entrez]
AID - 10.4321/s0212-71992005000400005 [doi]
PST - ppublish
SO  - An Med Interna. 2005 Apr;22(4):177-81. doi: 10.4321/s0212-71992005000400005.