PMID- 16005098
OWN - NLM
STAT- MEDLINE
DCOM- 20060613
LR  - 20111117
IS  - 0168-8227 (Print)
IS  - 0168-8227 (Linking)
VI  - 71
IP  - 2
DP  - 2006 Feb
TI  - Interleukin-12p40 gene (IL-12B) polymorphism and Type 1 diabetes mellitus in 
      Japanese: possible role in subjects without having high-risk HLA haplotypes.
PG  - 164-9
AB  - The present study was undertaken to clarify a role of interleukin-12p40 gene 
      (IL-12B) polymorphism, located on chromosome 5q33-34 (IDDM 18), in Japanese 
      subjects with Type 1 diabetes mellitus (T1DM) and autoimmune thyroid diseases 
      (AITD). In 179 subjects with T1DM, 166 with AITD (128 with Graves' disease and 38 
      with Hashimoto's thyroiditis) and 115 healthy control subjects, the IL-12B 3'UTR 
      A-C polymorphism was determined by PCR-RFLP method. In T1DM subjects, the 
      genotype was also analyzed in relation to human leukocyte antigen (HLA)-DRB1-DQB1 
      haplotype status. There was a weak difference in the distribution of the genotype 
      frequency between T1DM and control subjects, and the C allele frequency was 
      higher in T1DM subjects (P<0.05). In 68 T1DM subjects without having high-risk 
      HLA haplotypes to T1DM in this population, the genotype distribution and C allele 
      frequency was significantly different from control subjects without high-risk HLA 
      haplotypes (P<0.01), and from T1DM subjects with high-risk HLA haplotypes (n=111) 
      (P<0.05). There was no difference in the genotype and allele frequencies between 
      AITD and control subjects. In conclusion, the IL-12B 3'UTR A-C polymorphism did 
      not seem to play a major role on genetic susceptibility to T1DM and AITD in 
      Japanese, although the polymorphism conferred susceptibility in T1DM subjects 
      without having high-risk HLA haplotypes. The IL-12B 3'UTR A-C polymorphism would 
      be considered as a supplementary risk factor to T1DM in conjunction with HLA 
      haplotypes.
FAU - Yang, Jian Mei
AU  - Yang JM
AD  - Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical 
      School, Yakushiji 3311-1, Minamikawachi, Tochigi 329-0498, Japan.
FAU - Nagasaka, Shoichiro
AU  - Nagasaka S
FAU - Yatagai, Toshimitsu
AU  - Yatagai T
FAU - Nakamura, Tomoatsu
AU  - Nakamura T
FAU - Kusaka, Ikuyo
AU  - Kusaka I
FAU - Ishikawa, San-e
AU  - Ishikawa SE
FAU - Saito, Toshikazu
AU  - Saito T
FAU - Ishibashi, Shun
AU  - Ishibashi S
LA  - eng
PT  - Journal Article
DEP - 20050706
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (IL12B protein, human)
RN  - 0 (Interleukin-12 Subunit p40)
RN  - 187348-17-0 (Interleukin-12)
SB  - IM
MH  - Age of Onset
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 3
MH  - Diabetes Mellitus, Type 1/*genetics/*immunology
MH  - *HLA Antigens
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Interleukin-12/*genetics
MH  - Interleukin-12 Subunit p40
MH  - Japan
MH  - *Polymorphism, Genetic
MH  - *Polymorphism, Single Nucleotide
EDAT- 2005/07/12 09:00
MHDA- 2006/06/14 09:00
CRDT- 2005/07/12 09:00
PHST- 2004/11/22 00:00 [received]
PHST- 2005/05/02 00:00 [revised]
PHST- 2005/05/26 00:00 [accepted]
PHST- 2005/07/12 09:00 [pubmed]
PHST- 2006/06/14 09:00 [medline]
PHST- 2005/07/12 09:00 [entrez]
AID - S0168-8227(05)00225-1 [pii]
AID - 10.1016/j.diabres.2005.05.005 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2006 Feb;71(2):164-9. doi: 
      10.1016/j.diabres.2005.05.005. Epub 2005 Jul 6.