PMID- 16005173
OWN - NLM
STAT- MEDLINE
DCOM- 20060209
LR  - 20191210
IS  - 0531-5565 (Print)
IS  - 0531-5565 (Linking)
VI  - 40
IP  - 7
DP  - 2005 Jul
TI  - Effects of caloric restriction on post-spawning death of ayu.
PG  - 556-61
AB  - Caloric restriction (CR) is the only established intervention that extends life 
      span in mammals, insects and nematodes. One of the hypotheses suggested that most 
      of the effects of CR on aging may be due to reduced oxidative stress at the 
      cellular level. It was known that ayu (Plecoglossus altivelis) produced ROS 
      higher than other fish and that the life span of ayu is only one year. The 
      present study attempts to quantify age-associated changes of the degree of 
      attenuation on oxidative damage and hormonal homeostases in CR. The levels of 
      8-OHdG as the oxidative DNA damage level and the caspase-9/6, -3-like activities 
      as the induction factors of apoptosis with aging in brain and liver were 
      surveyed. Caspase-like activities in brain and liver were reduced by CR, while CR 
      had no influence on DNA damage level. However, life span of ayu was not prolonged 
      by CR. These results suggested that there would be factors determining life span 
      of ayu other than CR and apoptosis.
FAU - Nagasaka, Reiko
AU  - Nagasaka R
AD  - Department of Marine Biosciences, Tokyo University of Marine Science and 
      Technology, Minato, Japan.
FAU - Okamoto, Nobuaki
AU  - Okamoto N
FAU - Ushio, Hideki
AU  - Ushio H
LA  - eng
PT  - Journal Article
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
RN  - 88847-89-6 (8-Hydroxy-2'-Deoxyguanosine)
RN  - EC 3.4.22.- (Caspases)
RN  - G9481N71RO (Deoxyguanosine)
SB  - IM
MH  - 8-Hydroxy-2'-Deoxyguanosine
MH  - Aging/*physiology
MH  - Animals
MH  - Apoptosis/physiology
MH  - Body Weight/physiology
MH  - Brain/metabolism
MH  - Caspases/metabolism
MH  - DNA Damage/physiology
MH  - Deoxyguanosine/analogs & derivatives/analysis
MH  - Diet/*methods
MH  - Energy Intake/*physiology
MH  - Female
MH  - Homeostasis/physiology
MH  - Liver/metabolism
MH  - Longevity/physiology
MH  - Male
MH  - Mutation/genetics
MH  - Organ Size/physiology
MH  - Osmeriformes/genetics/*physiology
MH  - Oxidation-Reduction
MH  - Oxidative Stress/physiology
EDAT- 2005/07/12 09:00
MHDA- 2006/02/10 09:00
CRDT- 2005/07/12 09:00
PHST- 2005/02/04 00:00 [received]
PHST- 2005/05/10 00:00 [revised]
PHST- 2005/05/19 00:00 [accepted]
PHST- 2005/07/12 09:00 [pubmed]
PHST- 2006/02/10 09:00 [medline]
PHST- 2005/07/12 09:00 [entrez]
AID - S0531-5565(05)00091-4 [pii]
AID - 10.1016/j.exger.2005.05.003 [doi]
PST - ppublish
SO  - Exp Gerontol. 2005 Jul;40(7):556-61. doi: 10.1016/j.exger.2005.05.003.