PMID- 16007878
OWN - NLM
STAT- MEDLINE
DCOM- 20050826
LR  - 20191109
IS  - 0902-4506 (Print)
IS  - 0902-4506 (Linking)
IP  - 66
DP  - 2005 Jul
TI  - How to define intermediate stage in Hodgkin's lymphoma?
PG  - 111-4
AB  - BACKGROUND: Intermediate or unfavourable stage Hodgkin's lymphoma (HL) definition 
      relies upon at least three different scoring systems defined by cooperative 
      groups (EORTC, GHSG and Canadian-ECOG). We aimed to investigate their efficacy 
      and their correlation with International Prognostic Score (IPS) for advanced HL. 
      PATIENTS AND METHODS: We studied a population of 1156 patients with localized 
      stage HL treated prospectively within GELA centres in H8 (518 patients) and H9 
      (638 patients) protocols. Median age: 30 yr, 18%, Female 50%; stage I: 25%; stage 
      II: 75%. According to scoring systems 70% had 0-1 EORTC factors; 60% 0-1 GHSG 
      factors and 82% 0-1 Canadian factors. The IPS for advanced stages was available 
      only in H9 study with 64% 0-1 factor. RESULTS: Survival curves according to each 
      of the different scoring systems could significantly discriminate the subgroup 
      populations. When a multivariate Cox analysis was performed for overall survival 
      (OS) including all the scoring system variables: age > 45 yr, sex male, 
      Haemoglobin < 10.5 g/dL, lymphocytes < 600/microL, B symptoms with elevated ESR, 
      extra nodal sites did retain an independent significant value. Probability of OS 
      was 99%, 98%, 92%, 82% and 73% for patients with 1-5 factors, respectively P < 
      0.0001. CONCLUSION: These factors are similar for most of them with those 
      described in the IPS when stages III and IV are replaced by extra nodal 
      localization. This new score should be validated in other prospective trials, as 
      it will simplify the Hodgkin prognostic scoring systems for localized and 
      advanced stages.
FAU - Gisselbrecht, C
AU  - Gisselbrecht C
AD  - Service d'Hemato-Oncologie, INSERM ERM0220 Hopital Saint Louis, Paris, France. 
      christian.gisselbrecht@sls.ap-hop-paris.fr
FAU - Mounier, N
AU  - Mounier N
FAU - Andre, M
AU  - Andre M
FAU - Casanovas, O
AU  - Casanovas O
FAU - Reman, O
AU  - Reman O
FAU - Sebban, C
AU  - Sebban C
FAU - Divine, M
AU  - Divine M
FAU - Brice, P
AU  - Brice P
FAU - Briere, J
AU  - Briere J
FAU - Hennequin, C
AU  - Hennequin C
FAU - Ferme, C
AU  - Ferme C
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - England
TA  - Eur J Haematol Suppl
JT  - European journal of haematology. Supplementum
JID - 8703474
SB  - IM
MH  - Adult
MH  - Female
MH  - Hodgkin Disease/mortality/*pathology/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Neoplasm Staging/methods
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 2005/07/13 09:00
MHDA- 2005/08/27 09:00
CRDT- 2005/07/13 09:00
PHST- 2005/07/13 09:00 [pubmed]
PHST- 2005/08/27 09:00 [medline]
PHST- 2005/07/13 09:00 [entrez]
AID - 10.1111/j.1600-0609.2005.00463.x [doi]
PST - ppublish
SO  - Eur J Haematol Suppl. 2005 Jul;(66):111-4. doi: 10.1111/j.1600-0609.2005.00463.x.