PMID- 16008846
OWN - NLM
STAT- MEDLINE
DCOM- 20060721
LR  - 20140226
IS  - 0578-1426 (Print)
IS  - 0578-1426 (Linking)
VI  - 44
IP  - 6
DP  - 2005 Jun
TI  - [Clinical and cytogenetical study on subacute myeloid leukemia in myelodysplastic 
      syndromes].
PG  - 407-10
AB  - OBJECTIVE: To discuss from the clinical and cytogenetic aspect that part of 
      patients now diagnosed as myelodysplastic syndromes (MDS) could be diagnosed 
      early as leukemia and be classified as subacute myeloid leukemia (Sub-AML). 
      METHODS: Totally 173 patients diagnosed as MDS according to FAB or WHO criteria 
      with complete clinical and cytogenetical data were included in this research. 
      Among them 42 had +8 chromosome aberration, 16 had -7/7q-, and 55 had normal 
      karyotypes and more than 0.10 blast cells in the bone marrow. Short term culture 
      and G-banding techniques and in some specimens fluorescence in situ hybridization 
      (FISH) method were used to do chromosome analysis. RESULTS: Among the detected 
      chromosome aberrations, +8 was the most frequent (42.8%) and then -7/7q-(15.0%); 
      42 patients with +8 had median blast cell count of 0.08, within a median of 18 
      months follow-up period 40.0% of the patients evolved to frank leukemia (FL) and 
      the median overall survival was 20 months. 16 patients with -7/7q- had higher 
      blast cell count of 0.135; 43.8% of them developed into FL and the median overall 
      survival was only 10 months within a 20-month follow-up period. 55 patients had 
      normal karyotype but a median blast cell count of 0.148; 52.7% of them patients 
      evolved to FL and the median overall survival was 34 months. CONCLUSIONS: Both 
      the +8 and -7/7q- groups have malignant leukemic cell clone, and run a subacute 
      and progressive clinical course; it is suggested they might be classified into 
      Sub-AML. We should keep close watch on the patients who have normal karyotype yet 
      more than 0.10 blast cells, part of whom might suffer from early Sub-AML.
FAU - Qiu, Jing-ying
AU  - Qiu JY
AD  - People's Hospital of Peking University, Peking University Institute of 
      Hematology, Beijing 100044, China. lscm2@yahoo.com
FAU - Zhang, Yan
AU  - Zhang Y
FAU - Lu, Dao-pei
AU  - Lu DP
FAU - Lai, Yue-yun
AU  - Lai YY
FAU - He, Qi
AU  - He Q
FAU - Shi, Yan
AU  - Shi Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Nei Ke Za Zhi
JT  - Zhonghua nei ke za zhi
JID - 16210490R
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Chromosome Aberrations
MH  - Cytogenetic Analysis
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Leukemia, Myeloid, Acute/classification/diagnosis/*genetics
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/diagnosis/*genetics
EDAT- 2005/07/13 09:00
MHDA- 2006/07/22 09:00
CRDT- 2005/07/13 09:00
PHST- 2005/07/13 09:00 [pubmed]
PHST- 2006/07/22 09:00 [medline]
PHST- 2005/07/13 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Nei Ke Za Zhi. 2005 Jun;44(6):407-10.