PMID- 16009882
OWN - NLM
STAT- MEDLINE
DCOM- 20060224
LR  - 20161124
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 65
IP  - 1
DP  - 2005 Jul 12
TI  - Assessment of CE-MRA for the rapid detection of supra-aortic vascular disease.
PG  - 27-32
AB  - BACKGROUND: Contrast-enhanced MR angiography (CE-MRA) using a combined head and 
      neck coil permits non-invasive imaging of the vasculature from the aortic arch 
      through to the Circle of Willis in less than 2 minutes. OBJECTIVE: To determine 
      the accuracy of CE-MRA for the detection of vascular pathology, in particular 
      vascular stenoses, using digital subtraction angiography (DSA) as the gold 
      standard. METHODS: In a prospective study of 81 patients referred for DSA, CE-MRA 
      and DSA studies were performed within 72 hours of each other. CE-MRA was 
      performed on a 1.5 Tesla clinical MRI scanner using a five-channel neurovascular 
      array (head and neck coil), with dynamic tracking of the IV gadolinium bolus. 
      CE-MRAs and DSA films were read by two interventional neuroradiologists blinded 
      to the clinical presentation of the patient. RESULTS: On DSA, there were 77 
      vascular stenoses > or =50% identified, 51 extracranial and 26 intracranial. The 
      overall sensitivity of CE-MRA using the neurovascular array for the detection of 
      vascular stenoses > or =50% was 57% (95% CI: 46 to 68%) with a specificity of 98% 
      (97 to 99%). The sensitivity for the detection of extracranial vascular stenoses 
      > or =50% was 82% (72 to 93%) with a specificity of 97% (96 to 98%). However, the 
      sensitivity for the detection of intracranial vascular stenoses > or =50% was 
      only 8% (0 to 18%), with a specificity of 99% (98 to 100%). CONCLUSIONS: At this 
      stage Contrast-enhanced MR angiography using a neurovascular coil shows promise 
      as a rapid, specific, and noninvasive screening method for extracranial vascular 
      disease, but not for intracranial vascular disease.
FAU - Wright, V L
AU  - Wright VL
AD  - Stroke Neuroscience Unit, NINDS/NIH, 10 Center Drive, MSC 1294, Room 3N258, 
      Bethesda, MD 20892-1294, USA.
FAU - Olan, W
AU  - Olan W
FAU - Dick, B
AU  - Dick B
FAU - Yu, H
AU  - Yu H
FAU - Alberts-Grill, N
AU  - Alberts-Grill N
FAU - Latour, L L
AU  - Latour LL
FAU - Baird, A E
AU  - Baird AE
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
RN  - 0 (Contrast Media)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Angiography, Digital Subtraction/adverse effects/*standards
MH  - Carotid Artery Diseases/diagnosis
MH  - Carotid Artery, External/diagnostic imaging/pathology
MH  - Carotid Artery, Internal/diagnostic imaging/pathology
MH  - Carotid Stenosis/diagnosis
MH  - Cerebral Arteries/diagnostic imaging/pathology
MH  - Cerebrovascular Disorders/*diagnosis/physiopathology/therapy
MH  - Contrast Media/*standards
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Angiography/instrumentation/*methods/*standards
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Stroke/diagnosis/prevention & control
MH  - Time Factors
EDAT- 2005/07/13 09:00
MHDA- 2006/02/25 09:00
CRDT- 2005/07/13 09:00
PHST- 2005/07/13 09:00 [pubmed]
PHST- 2006/02/25 09:00 [medline]
PHST- 2005/07/13 09:00 [entrez]
AID - 65/1/27 [pii]
AID - 10.1212/01.wnl.0000167606.81882.68 [doi]
PST - ppublish
SO  - Neurology. 2005 Jul 12;65(1):27-32. doi: 10.1212/01.wnl.0000167606.81882.68.