PMID- 16013505
OWN - NLM
STAT- MEDLINE
DCOM- 20060714
LR  - 20181201
VI  - 19
IP  - 6
DP  - 2005 Mar
TI  - [Expression of Survivin and Bcl-2 in laryngeal squamous cell carcinoma and their 
      significance].
PG  - 247-9
AB  - OBJECTIVE: To research the expression of Survivin and Bcl-2 protein in laryngeal 
      squamous cell carcinoma (LSCC) and the correlation between them. METHOD: 
      Immunohistochemical (SP) method was used to detect the expression of Survivin and 
      Bcl-2 in 64 cases of LSCC, 28 cases of normal laryngeal mucous membrane and 20 
      cases of laryngeal benign lesion. The relationship among them was studied by 
      statistical analysis. RESULT: Survivin protein was expressed in 43 of 64 (67.2%) 
      samples of LSCC, just 2 samples was expressed in laryngeal benign lesion (10%) 
      and 1 sample expressed in normal laryngeal mucosa (3.6%). The over expression of 
      Survivin was related to the tumor's location, clinical stage, histological grade, 
      lymphatic metastasis. The expression of Survivin was correlated with the 
      expression of Bcl-2. CONCLUSION: Survivin may play an important role in the 
      pathway of carcinogenesis, progress and metastasis of LSCC,it is feasible for 
      early diagnosis and precaution. Bcl-2 and Survivin may play synergetic roles in 
      the pathogenesis of LSCC.
FAU - Wang, Jizhe
AU  - Wang J
AD  - Department of Otorhinolaryngology, the First Affiliated Hospital of China Medical 
      University, Shenyang, 110001, China. wangjizhe2004@sina.com
FAU - Guan, Chao
AU  - Guan C
FAU - Wang, Shouchen
AU  - Wang S
FAU - Chen, Bin
AU  - Chen B
FAU - Sun, Jialiang
AU  - Sun J
FAU - Ji, Wenyue
AU  - Ji W
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
RN  - 0 (BIRC5 protein, human)
RN  - 0 (Inhibitor of Apoptosis Proteins)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (Survivin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Female
MH  - Humans
MH  - Inhibitor of Apoptosis Proteins
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Male
MH  - Microtubule-Associated Proteins/*biosynthesis
MH  - Middle Aged
MH  - Neoplasm Proteins/*biosynthesis
MH  - Proto-Oncogene Proteins c-bcl-2/*biosynthesis
MH  - Survivin
EDAT- 2005/07/15 09:00
MHDA- 2006/07/15 09:00
CRDT- 2005/07/15 09:00
PHST- 2005/07/15 09:00 [pubmed]
PHST- 2006/07/15 09:00 [medline]
PHST- 2005/07/15 09:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Mar;19(6):247-9.