PMID- 16014923
OWN - NLM
STAT- MEDLINE
DCOM- 20050818
LR  - 20240109
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 79
IP  - 15
DP  - 2005 Aug
TI  - Gene expression and antiviral activity of alpha/beta interferons and 
      interleukin-29 in virus-infected human myeloid dendritic cells.
PG  - 9608-17
AB  - Dendritic cells (DCs) respond to microbial infections by undergoing phenotypic 
      maturation and by producing multiple cytokines. In the present study, we analyzed 
      the ability of influenza A and Sendai viruses to induce DC maturation and 
      activate tumor necrosis factor alpha (TNF-alpha), alpha/beta interferon 
      (IFN-alpha/beta), and IFN-like interleukin-28A/B (IFN-lambda2/3) and IL-29 
      (IFN-lambda1) gene expression in human monocyte-derived myeloid DCs (mDC). The 
      ability of influenza A virus to induce mDC maturation or enhance the expression 
      of TNF-alpha, IFN-alpha/beta, interleukin-28 (IL-28), and IL-29 genes was 
      limited, whereas Sendai virus efficiently induced mDC maturation and enhanced 
      cytokine gene expression. Influenza A virus-induced expression of TNF-alpha, 
      IFN-alpha, IFN-beta, IL-28, and IL-29 genes was, however, dramatically enhanced 
      when cells were pretreated with IFN-alpha. IFN-alpha priming led to increased 
      expression of Toll-like receptor 3 (TLR3), TLR7, TLR8, MyD88, TRIF, and IFN 
      regulatory factor 7 (IRF7) genes and enhanced influenza-induced phosphorylation 
      and DNA binding of IRF3. Influenza A virus also enhanced the binding of NF-kappaB 
      to the respective NF-kappaB elements of the promoters of IFN-beta and IL-29 
      genes. In mDC IL-29 induced MxA protein expression and possessed antiviral 
      activity against influenza A virus, although this activity was lower than that of 
      IFN-alpha or IFN-beta. Our results show that in human mDCs viruses can readily 
      induce the expression of IL-28 and IL-29 genes whose gene products are likely to 
      contribute to the host antiviral response.
FAU - Osterlund, Pamela
AU  - Osterlund P
AD  - Department of Viral Diseases and Immunology, National Public Health Institute, 
      Helsinki, Finland.
FAU - Veckman, Ville
AU  - Veckman V
FAU - Siren, Jukka
AU  - Siren J
FAU - Klucher, Kevin M
AU  - Klucher KM
FAU - Hiscott, John
AU  - Hiscott J
FAU - Matikainen, Sampsa
AU  - Matikainen S
FAU - Julkunen, Ilkka
AU  - Julkunen I
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Adaptor Proteins, Vesicular Transport)
RN  - 0 (Antigens, Differentiation)
RN  - 0 (Antiviral Agents)
RN  - 0 (Cytokines)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (interferon-lambda, human)
RN  - 0 (IRF3 protein, human)
RN  - 0 (Interferon Regulatory Factor-3)
RN  - 0 (Interferon-alpha)
RN  - 0 (Interleukins)
RN  - 0 (MYD88 protein, human)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Myeloid Differentiation Factor 88)
RN  - 0 (NF-kappa B)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (TICAM1 protein, human)
RN  - 0 (TLR3 protein, human)
RN  - 0 (TLR7 protein, human)
RN  - 0 (TLR8 protein, human)
RN  - 0 (Toll-Like Receptor 3)
RN  - 0 (Toll-Like Receptor 7)
RN  - 0 (Toll-Like Receptor 8)
RN  - 0 (Toll-Like Receptors)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 77238-31-4 (Interferon-beta)
RN  - 9008-11-1 (Interferons)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Adaptor Proteins, Vesicular Transport/biosynthesis/genetics
MH  - Antigens, Differentiation/biosynthesis/genetics
MH  - Antiviral Agents/genetics/pharmacology
MH  - Cell Differentiation
MH  - Cells, Cultured
MH  - Cytokines
MH  - DNA-Binding Proteins/biosynthesis/genetics
MH  - Dendritic Cells/cytology/metabolism/virology
MH  - Gene Expression/drug effects
MH  - Humans
MH  - Influenza A virus/*physiology
MH  - Interferon Regulatory Factor-3
MH  - Interferon-alpha/*biosynthesis/pharmacology
MH  - Interferon-beta/*biosynthesis/pharmacology
MH  - Interferons
MH  - Interleukins/*biosynthesis/pharmacology
MH  - Membrane Glycoproteins/biosynthesis/genetics
MH  - Myeloid Differentiation Factor 88
MH  - NF-kappa B/metabolism
MH  - Promoter Regions, Genetic
MH  - RNA, Messenger/analysis
MH  - Receptors, Cell Surface/biosynthesis/genetics
MH  - Receptors, Immunologic/biosynthesis/genetics
MH  - Sendai virus/*physiology
MH  - Toll-Like Receptor 3
MH  - Toll-Like Receptor 7
MH  - Toll-Like Receptor 8
MH  - Toll-Like Receptors
MH  - Transcription Factors/biosynthesis/genetics
MH  - Tumor Necrosis Factor-alpha/biosynthesis/pharmacology
PMC - PMC1181545
EDAT- 2005/07/15 09:00
MHDA- 2005/08/19 09:00
PMCR- 2005/08/01
CRDT- 2005/07/15 09:00
PHST- 2005/07/15 09:00 [pubmed]
PHST- 2005/08/19 09:00 [medline]
PHST- 2005/07/15 09:00 [entrez]
PHST- 2005/08/01 00:00 [pmc-release]
AID - 79/15/9608 [pii]
AID - 0022-05 [pii]
AID - 10.1128/JVI.79.15.9608-9617.2005 [doi]
PST - ppublish
SO  - J Virol. 2005 Aug;79(15):9608-17. doi: 10.1128/JVI.79.15.9608-9617.2005.