PMID- 16014973
OWN - NLM
STAT- MEDLINE
DCOM- 20050818
LR  - 20220311
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 79
IP  - 15
DP  - 2005 Aug
TI  - A new common integration site, Int7, for the mouse mammary tumor virus in mouse 
      mammary tumors identifies a gene whose product has furin-like and 
      thrombospondin-like sequences.
PG  - 10093-6
AB  - A novel common integration site for the mouse mammary tumor virus (MMTV) was 
      identified (designated Int7) in five independently arising mouse mammary tumors. 
      The insertion sites all cluster within a 1-kb region that is 2 to 3 kb 5' of the 
      transcription initiation site of a gene, 2610028F08RIK, whose gene product 
      contains furin-like and thrombospondin-like sequences. Expression of Int7 is 
      normally very low or silent during various stages of mammary gland development, 
      but MMTV integration at this site results in the activation of high steady-state 
      levels of expression of the gene. These five tumors were also found to have two 
      or three additional viral insertions, which in each case occurred flanking a 
      member of either the Wnt and/or FGF gene family. Reverse transcriptase PCR 
      results demonstrated that each of the viral insertions led to elevated expression 
      of the presumed target flanking genes.
FAU - Lowther, William
AU  - Lowther W
AD  - Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, 
      Bethesda, MD 20892, USA.
FAU - Wiley, Korah
AU  - Wiley K
FAU - Smith, Gilbert H
AU  - Smith GH
FAU - Callahan, Robert
AU  - Callahan R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Thrombospondin 1)
RN  - EC 3.4.21.75 (Furin)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Chromosomes/*genetics
MH  - Female
MH  - Furin
MH  - Mammary Neoplasms, Experimental/*genetics
MH  - Mammary Tumor Virus, Mouse/*physiology
MH  - Mice/*genetics/virology
MH  - Molecular Sequence Data
MH  - Retroviridae Infections/*genetics
MH  - Thrombospondin 1
MH  - Tumor Virus Infections/*genetics
MH  - *Virus Integration
PMC - PMC1181551
EDAT- 2005/07/15 09:00
MHDA- 2005/08/19 09:00
PMCR- 2005/08/01
CRDT- 2005/07/15 09:00
PHST- 2005/07/15 09:00 [pubmed]
PHST- 2005/08/19 09:00 [medline]
PHST- 2005/07/15 09:00 [entrez]
PHST- 2005/08/01 00:00 [pmc-release]
AID - 79/15/10093 [pii]
AID - 0074-05 [pii]
AID - 10.1128/JVI.79.15.10093-10096.2005 [doi]
PST - ppublish
SO  - J Virol. 2005 Aug;79(15):10093-6. doi: 10.1128/JVI.79.15.10093-10096.2005.