PMID- 16015021
OWN - NLM
STAT- MEDLINE
DCOM- 20060203
LR  - 20131121
IS  - 1660-5527 (Print)
IS  - 1660-5527 (Linking)
VI  - 18
IP  - 5
DP  - 2005 Sep-Oct
TI  - Acebutolol-induced subacute cutaneous lupus erythematosus.
PG  - 230-3
AB  - Beta-blocking medications are rarely associated with drug-induced lupus 
      erythematosus syndrome and have never been incriminated as a cause of subacute 
      lupus erythematosus (SCLE). We present herein the first case of SCLE induced by 
      acebutolol. A 57-year-old woman presented with a 1-month history of a cutaneous 
      eruption of the photo-exposed areas. One month ago, the patient had started a 
      treatment with oral acebutolol to cure a hypertension of 1-year evolution. 
      Physical examination revealed erythematous scaly annular plaques, involving the 
      face, arms and trunk. Immunologic serology findings revealed a positive titer of 
      antinuclear antibodies up to 1/1,280 with positivity of antihistone and Ro/SSA 
      antibodies. Acebutolol was stopped, and the lesions cleared completely 4 months 
      later. Literature data, along with our case, suggest a link between acebutolol 
      therapy and the onset of a lupus syndrome. Although this is the first report of 
      acebutolol-induced SCLE, we should be aware of this occurrence, and avoidance of 
      acebutolol is recommended in patients with stigmata of lupus erythematosus.
CI  - Copyright 2005 S. Karger AG, Basel
FAU - Fenniche, S
AU  - Fenniche S
AD  - Dermatology Department, Habib Thameur Hospital, Tunis, Tunisia. 
      fenniche.samy@planet.tn
FAU - Dhaoui, A
AU  - Dhaoui A
FAU - Ammar, F Ben
AU  - Ammar FB
FAU - Benmously, R
AU  - Benmously R
FAU - Marrak, H
AU  - Marrak H
FAU - Mokhtar, I
AU  - Mokhtar I
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20050705
PL  - Switzerland
TA  - Skin Pharmacol Physiol
JT  - Skin pharmacology and physiology
JID - 101188418
RN  - 0 (Adrenergic beta-Antagonists)
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (SS-A antibodies)
RN  - 67P356D8GH (Acebutolol)
SB  - IM
MH  - Acebutolol/*adverse effects
MH  - Adrenergic beta-Antagonists/*adverse effects
MH  - Antibodies, Antinuclear/analysis
MH  - Female
MH  - Humans
MH  - Hypertension/drug therapy
MH  - Lupus Erythematosus, Cutaneous/*chemically induced/immunology/pathology
MH  - Middle Aged
EDAT- 2005/07/15 09:00
MHDA- 2006/02/04 09:00
CRDT- 2005/07/15 09:00
PHST- 2004/08/13 00:00 [received]
PHST- 2005/01/06 00:00 [accepted]
PHST- 2005/07/15 09:00 [pubmed]
PHST- 2006/02/04 09:00 [medline]
PHST- 2005/07/15 09:00 [entrez]
AID - 86668 [pii]
AID - 10.1159/000086668 [doi]
PST - ppublish
SO  - Skin Pharmacol Physiol. 2005 Sep-Oct;18(5):230-3. doi: 10.1159/000086668. Epub 
      2005 Jul 5.