PMID- 16018898
OWN - NLM
STAT- MEDLINE
DCOM- 20051027
LR  - 20131121
IS  - 0045-6535 (Print)
IS  - 0045-6535 (Linking)
VI  - 60
IP  - 9
DP  - 2005 Sep
TI  - Partitioning of polychlorinated biphenyls in octanol/water, triolein/water, and 
      membrane/water systems.
PG  - 1270-8
AB  - The use of the octanol/water partition constant (Kow) as a surrogate parameter 
      for lipid/water partitioning of persistent organic pollutants (POPs) was 
      reassessed by comparing the measured Kow of 12 selected polychlorinated biphenyl 
      congeners (PCBs) with partition constants in triolein/water (Ktw) and 
      membrane/water (Kmw) systems. Kow and Ktw were measured by the slow-stirring 
      method. Kmw was measured by an adaptation of the slow-stirring method using 
      suspensions of phosphatidylcholine and phosphatidylserine liposomes. Partitioning 
      of POPs to octanol, triolein, and liposomes is similar but not equal. The log-log 
      correlation for Kow and Ktw is excellent (r2 = 0.982) and that for Kow and Kmw is 
      somewhat weaker (r2 = 0.856). Ktw values are greater than Kow by a factor of 1.6. 
      Kmw of some PCB congeners exceed both Kow and Ktw by an order of magnitude. The 
      differences are attributed to different PCB activity coefficients in the 
      different lipid phases. The results imply that Kow can be used as a reasonable 
      conservative estimate of lipid/water partitioning. But the observed differences 
      between Kow and Kmw also indicate that using Kow to predict accumulation of POPs, 
      particularly highly hydrophobic ones, in the polar lipids of organisms will 
      underestimate their concentrations at equilibrium.
FAU - Jabusch, Thomas W
AU  - Jabusch TW
AD  - Division of Environmental Health Sciences, School of Public Health, University of 
      Minnesota, Mayo Mail Code 807, Minneapolis, MN 55455, USA.
FAU - Swackhamer, Deborah L
AU  - Swackhamer DL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - 0 (Environmental Pollutants)
RN  - 0 (Lipids)
RN  - 0 (Liposomes)
RN  - 0 (Octanols)
RN  - 059QF0KO0R (Water)
RN  - 122-32-7 (Triolein)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Animals
MH  - Environmental Pollutants
MH  - Hydrophobic and Hydrophilic Interactions
MH  - Lipids/chemistry
MH  - Liposomes/*chemistry
MH  - Octanols/*chemistry
MH  - Polychlorinated Biphenyls/*chemistry
MH  - Solubility
MH  - Triolein/*chemistry
MH  - Water/*chemistry
EDAT- 2005/07/16 09:00
MHDA- 2005/10/28 09:00
CRDT- 2005/07/16 09:00
PHST- 2003/08/13 00:00 [received]
PHST- 2004/11/30 00:00 [revised]
PHST- 2005/01/21 00:00 [accepted]
PHST- 2005/07/16 09:00 [pubmed]
PHST- 2005/10/28 09:00 [medline]
PHST- 2005/07/16 09:00 [entrez]
AID - S0045-6535(05)00196-7 [pii]
AID - 10.1016/j.chemosphere.2005.01.076 [doi]
PST - ppublish
SO  - Chemosphere. 2005 Sep;60(9):1270-8. doi: 10.1016/j.chemosphere.2005.01.076.