PMID- 16019923
OWN - NLM
STAT- MEDLINE
DCOM- 20050811
LR  - 20220331
IS  - 0955-3002 (Print)
IS  - 0955-3002 (Linking)
VI  - 81
IP  - 2
DP  - 2005 Feb
TI  - Translocation yields in peripheral blood lymphocytes from control populations.
PG  - 139-45
AB  - PURPOSE: To record the latest information on control levels of translocations in 
      cultured human lymphocytes. MATERIALS AND METHODS: Control-level data from seven 
      European laboratories that are using fluorescence in situ hybridization (FISH) 
      techniques for retrospective biological dosimetry have been combined in a 
      meta-analysis. After correction for the differing probe combinations used, tests 
      of consistency are performed. The combined data have been used to test for 
      individual variation, systematic variation with age, gender and smoking habits. 
      RESULTS: There is a strong variation of translocation yield with age but no 
      variation was detectable with gender or smoking habits. After correction for age, 
      homogeneity tests showed that about 10% of individuals were outside the 95% 
      confidence limits as opposed to 5% expected. From a total of 385, there is an 
      excess of about 20 individuals most of whom have an unexpectedly high yield of 
      translocations. CONCLUSIONS: For retrospective biological dosimetry purposes a 
      generic age-dependent control level can be assumed. No other lifestyle factors 
      such as smoking appear to have a significant effect on translocation yield.
FAU - Whitehouse, C A
AU  - Whitehouse CA
AD  - Westlakes Research Institute, Cumbria, UK.
FAU - Edwards, A A
AU  - Edwards AA
FAU - Tawn, E J
AU  - Tawn EJ
FAU - Stephan, G
AU  - Stephan G
FAU - Oestreicher, U
AU  - Oestreicher U
FAU - Moquet, J E
AU  - Moquet JE
FAU - Lloyd, D C
AU  - Lloyd DC
FAU - Roy, L
AU  - Roy L
FAU - Voisin, P
AU  - Voisin P
FAU - Lindholm, C
AU  - Lindholm C
FAU - Barquinero, J
AU  - Barquinero J
FAU - Barrios, L
AU  - Barrios L
FAU - Caballin, M R
AU  - Caballin MR
FAU - Darroudi, F
AU  - Darroudi F
FAU - Fomina, J
AU  - Fomina J
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Radiat Biol
JT  - International journal of radiation biology
JID - 8809243
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Distribution
MH  - Aged
MH  - Background Radiation
MH  - Child
MH  - Europe/epidemiology
MH  - Female
MH  - Humans
MH  - Lymphocytes/*cytology/*radiation effects
MH  - Male
MH  - Middle Aged
MH  - Radiation Monitoring/methods
MH  - Reference Values
MH  - Risk Assessment/*methods
MH  - Risk Factors
MH  - Sex Distribution
MH  - Smoking/*epidemiology
MH  - Translocation, Genetic/*genetics/*radiation effects
MH  - United States/epidemiology
EDAT- 2005/07/16 09:00
MHDA- 2005/08/12 09:00
CRDT- 2005/07/16 09:00
PHST- 2005/07/16 09:00 [pubmed]
PHST- 2005/08/12 09:00 [medline]
PHST- 2005/07/16 09:00 [entrez]
AID - X9RM18W6277M2JJ1 [pii]
AID - 10.1080/09553000500103082 [doi]
PST - ppublish
SO  - Int J Radiat Biol. 2005 Feb;81(2):139-45. doi: 10.1080/09553000500103082.