PMID- 16021676
OWN - NLM
STAT- MEDLINE
DCOM- 20051027
LR  - 20220408
IS  - 0022-3417 (Print)
IS  - 0022-3417 (Linking)
VI  - 207
IP  - 1
DP  - 2005 Sep
TI  - Different proportions of aneusomic cells in ovarian inclusion cysts associated 
      with serous borderline tumours and serous high-grade carcinomas support different 
      pathogenetic pathways.
PG  - 20-6
AB  - Ovarian serous tumours may arise from the ovarian surface epithelium or from 
      ovarian cortical epithelial inclusion cysts. However, little is known about the 
      pathogenetic mechanisms involved in the progression from ovarian surface 
      epithelium or inclusion cysts to neoplastic disease. In the present study, 
      chromosomal aberrations typical of ovarian serous tumours were studied in ovarian 
      surface epithelium and inclusion cysts. Ten ovaries with inclusion cysts obtained 
      from patients without a gynaecological tumour, as well as 15 serous borderline 
      tumours and 16 invasive high-grade serous carcinomas with inclusion cysts either 
      in the ipsi- or in the contralateral ovary, were investigated by fluorescence in 
      situ hybridization (FISH) using centromere enumeration probes directed against 
      chromosomes 1, 6, 7, and X. The proportions of aneusomic cells were assessed. 
      Trisomies 1 and 7 and monosomies 6 and X were present in the surface epithelium, 
      inclusion cysts, and tumours, providing evidence for a link between the surface 
      epithelium, and inclusion cysts, and serous neoplasia. Inclusion cysts generally 
      harboured more aneusomic cells than the associated surface epithelium, suggesting 
      an influence of the ovarian stroma on the development of chromosomal instability. 
      Moreover, inclusion cysts associated with borderline tumours displayed a higher 
      proportion of aneusomic cells than inclusion cysts associated with invasive 
      high-grade carcinoma and than inclusion cysts in ovaries without neoplastic 
      disease. These results suggest a genetic field defect of the inclusion cyst 
      epithelium in serous borderline tumours. Invasive high-grade serous carcinomas, 
      by contrast, may arise from single cell clones subject to a different set of 
      genetic events.
CI  - Copyright (c) 2005 Pathological Society of Great Britain and Ireland. Published 
      by John Wiley & Sons, Ltd.
FAU - Korner, Meike
AU  - Korner M
AD  - Institute of Pathology, University of Bern, Bern, Switzerland. 
      meike.koerner@pathology.unibe.ch
FAU - Burckhardt, Elisabeth
AU  - Burckhardt E
FAU - Mazzucchelli, Luca
AU  - Mazzucchelli L
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Pathol
JT  - The Journal of pathology
JID - 0204634
SB  - IM
MH  - Aneuploidy
MH  - *Chromosome Aberrations
MH  - Cystadenocarcinoma, Serous/*genetics/pathology
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Ovarian Cysts/*genetics/pathology
MH  - Ovarian Neoplasms/*genetics/pathology
MH  - Precancerous Conditions/*genetics/pathology
EDAT- 2005/07/16 09:00
MHDA- 2005/10/28 09:00
CRDT- 2005/07/16 09:00
PHST- 2005/07/16 09:00 [pubmed]
PHST- 2005/10/28 09:00 [medline]
PHST- 2005/07/16 09:00 [entrez]
AID - 10.1002/path.1817 [doi]
PST - ppublish
SO  - J Pathol. 2005 Sep;207(1):20-6. doi: 10.1002/path.1817.