PMID- 16022110
OWN - NLM
STAT- MEDLINE
DCOM- 20050901
LR  - 20161124
IS  - 0869-6047 (Print)
IS  - 0869-6047 (Linking)
IP  - 6
DP  - 2005
TI  - [Pharmacogenomical aspects of gastroesophageal reflux disease].
PG  - 33-6
AB  - The article covers the modem concept of gastroesophageal reflux disease (GERD) 
      pharmacogenomics. Special attention is payed to polymorphism of CYP2C19 gene and 
      its influence on the metabolism of modern antisecretory agents, such as proton 
      pump inhibitors (PPI). The authors summarize data which demonstrate that the 
      differences in the pharmacodynamics and clinical effects of PPI are caused by 
      CYP2C19 gene polymorphism. The paper shows that this factor should be considered 
      when planning GERD therapy with PPI in order to achieve a complete remission and 
      make the therapy economically rational.
FAU - Isaev, V A
AU  - Isaev VA
LA  - rus
PT  - Journal Article
PL  - Russia (Federation)
TA  - Vestn Ross Akad Med Nauk
JT  - Vestnik Rossiiskoi akademii meditsinskikh nauk
JID - 9215641
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Benzimidazoles)
RN  - 0K5C5T2QPG (Lansoprazole)
RN  - 32828355LL (Rabeprazole)
RN  - EC 1.- (Mixed Function Oxygenases)
RN  - EC 1.14.14.1 (Aryl Hydrocarbon Hydroxylases)
RN  - EC 1.14.14.1 (CYP2C19 protein, human)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP2C19)
RN  - KG60484QX9 (Omeprazole)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles
MH  - Anti-Ulcer Agents/administration & dosage/*therapeutic use
MH  - Aryl Hydrocarbon Hydroxylases/genetics
MH  - Benzimidazoles/administration & dosage/*therapeutic use
MH  - Cytochrome P-450 CYP2C19
MH  - Drug Administration Schedule
MH  - Gastroesophageal Reflux/*drug therapy/genetics
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Lansoprazole
MH  - Mixed Function Oxygenases/genetics
MH  - Omeprazole/administration & dosage/*analogs & derivatives/therapeutic use
MH  - Polymorphism, Genetic
MH  - Rabeprazole
MH  - Remission Induction
MH  - Time Factors
EDAT- 2005/07/19 09:00
MHDA- 2005/09/02 09:00
CRDT- 2005/07/19 09:00
PHST- 2005/07/19 09:00 [pubmed]
PHST- 2005/09/02 09:00 [medline]
PHST- 2005/07/19 09:00 [entrez]
PST - ppublish
SO  - Vestn Ross Akad Med Nauk. 2005;(6):33-6.