PMID- 16025233
OWN - NLM
STAT- MEDLINE
DCOM- 20051220
LR  - 20191210
IS  - 0920-3206 (Print)
IS  - 0920-3206 (Linking)
VI  - 19
IP  - 2
DP  - 2005 Mar
TI  - Comparison of impedance cardiography and thermodilution-derived measurements of 
      stroke volume and cardiac output at rest and during exercise testing.
PG  - 141-7
AB  - BACKGROUND: Non-invasive evaluation of haemodynamic variables remains a 
      preferable and attractive option in both pharmacologic research and clinical 
      cardiology. OBJECTIVES: The objective of this study was to evaluate the 
      correlation, feasibility and diagnostic value of haemodynamic measurements by ICG 
      with the thermodilution (TD) method at rest and during exercise testing. METHODS: 
      We measured stroke volume (SV) and cardiac output (CO) with both methods in 20 
      patients with suspected coronary artery disease (CAD). All measurements were 
      performed simultaneously at rest and during bicycle exercise. RESULTS: There was 
      a highly significant correlation (p < 0.001) for measurements of SV between both 
      methods at rest (r = 0.83) and during exercise (r = 0.85-0.87) with 50-100 watts. 
      For measurements of CO, the respective correlations were r = 0.85 at rest and r = 
      0.92-0.94 during exercise. The mean difference for measurements of SV were 3.8 
      +/- 12.6 ml at rest and 6.5+/- 11.4 ml during exercise. For measurements of CO, 
      the mean difference between both methods was 0.9 +/- 1.0 l/min at rest and 1.0+/- 
      0.8 l/min during exercise. Compared to TD measurements, ICG had a bias to 
      overestimate SV and CO of approximately by 5-10%. One patient had to be excluded 
      because of inappropriate quality of the ICG signals during exercise. CONCLUSIONS: 
      ICG is a feasible and accurate method for non-invasive measurements of SV and CO. 
      Haemodynamic measurements by ICG were correlated highly significant to 
      simultaneous measurements by the TD method.
FAU - Scherhag, A
AU  - Scherhag A
AD  - I. Medical Clinic, University Hospital Mannheim, Faculty of Clinical Medicine 
      Mannheim, University of Heidelberg, D-68135 Mannheim, Germany. 
      armin.scherhag@roche.com
FAU - Kaden, J J
AU  - Kaden JJ
FAU - Kentschke, E
AU  - Kentschke E
FAU - Sueselbeck, T
AU  - Sueselbeck T
FAU - Borggrefe, M
AU  - Borggrefe M
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - Cardiovasc Drugs Ther
JT  - Cardiovascular drugs and therapy
JID - 8712220
SB  - IM
MH  - Aged
MH  - Cardiac Catheterization
MH  - Cardiac Output/physiology
MH  - Cardiography, Impedance
MH  - Coronary Angiography
MH  - Coronary Artery Disease/diagnosis/physiopathology
MH  - *Exercise Test
MH  - Female
MH  - Germany
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Rest/*physiology
MH  - Statistics as Topic
MH  - Stroke Volume/*physiology
MH  - Thermodilution
EDAT- 2005/07/19 09:00
MHDA- 2005/12/21 09:00
CRDT- 2005/07/19 09:00
PHST- 2005/07/19 09:00 [pubmed]
PHST- 2005/12/21 09:00 [medline]
PHST- 2005/07/19 09:00 [entrez]
AID - 10.1007/s10557-005-1048-0 [doi]
PST - ppublish
SO  - Cardiovasc Drugs Ther. 2005 Mar;19(2):141-7. doi: 10.1007/s10557-005-1048-0.