PMID- 16026747
OWN - NLM
STAT- MEDLINE
DCOM- 20051006
LR  - 20111117
IS  - 1521-6926 (Print)
IS  - 1521-6926 (Linking)
VI  - 18
IP  - 4
DP  - 2005
TI  - Heavy chain diseases.
PG  - 729-46
AB  - Heavy chain diseases (HCDs) are rare B-cell lymphoplasma-cell proliferative 
      disorders characterized by production of truncated monoclonal immunoglobulin 
      heavy chains without associated light chains. HCDs involving the three main 
      immunoglobulin classes have been described; alpha-HCD is the most common and has 
      the most uniform presentation, gamma- and mu-HCDs have variable clinical 
      presentations and histopathologic features. HCDs can be thought of as variant 
      types of non-Hodgkin lymphoma: alpha-HCD presents as an extranodal marginal-zone 
      lymphoma of mucosa-associated lymph-node tissue, gamma-HCD as lymphoplasmacytoid 
      non-Hodgkin lymphoma, and mu-HCD as small lymphocytic non-Hodgkin lymphoma or 
      chronic lymphocytic leukemia. Diagnosis of HCD requires documentation of a 
      deleted immunoglobulin heavy chain without a bound light chain in the serum or 
      urine. Prognosis is variable, and no standardized effective treatment programs 
      are available except for alpha-HCD, which in its early stage may respond to 
      antibiotics.
FAU - Wahner-Roedler, Dietlind L
AU  - Wahner-Roedler DL
AD  - Division of General Internal Medicine, Mayo Clinic, 200 First Street SW, 
      Rochester, MN 55905, USA. wahnerroedler.dietlind@mayo.edu
FAU - Kyle, Robert A
AU  - Kyle RA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Best Pract Res Clin Haematol
JT  - Best practice & research. Clinical haematology
JID - 101120659
RN  - 0 (Immunoglobulin Heavy Chains)
SB  - IM
MH  - Clinical Laboratory Techniques
MH  - Heavy Chain Disease/*diagnosis/drug therapy/genetics/pathology
MH  - Humans
MH  - Immunoglobulin Heavy Chains/genetics
MH  - Lymphoproliferative Disorders/etiology
MH  - Prognosis
RF  - 38
EDAT- 2005/07/20 09:00
MHDA- 2005/10/07 09:00
CRDT- 2005/07/20 09:00
PHST- 2005/07/20 09:00 [pubmed]
PHST- 2005/10/07 09:00 [medline]
PHST- 2005/07/20 09:00 [entrez]
AID - S1521-6926(05)00030-7 [pii]
AID - 10.1016/j.beha.2005.01.029 [doi]
PST - ppublish
SO  - Best Pract Res Clin Haematol. 2005;18(4):729-46. doi: 10.1016/j.beha.2005.01.029.