PMID- 16029430
OWN - NLM
STAT- MEDLINE
DCOM- 20050919
LR  - 20221207
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 66
IP  - 2
DP  - 2005 Aug
TI  - Frequencies of HLA-A, HLA-B, HLA-DR, and HLA-DQ phenotypes in the United Arab 
      Emirates population.
PG  - 107-13
AB  - The high degree of polymorphism of the human leukocyte antigen (HLA) system 
      provides means for the study of diversity in different populations. The aim of 
      this work is to study the HLA phenotype frequencies in the United Arab Emiratis 
      in comparison with other geographically related Arabs, Iranians, and Asians, all 
      living in the United Arab Emirates (UAE). Healthy blood donors and potential 
      kidney or bone marrow donors were typed for HLA class I (n = 1880) and class II 
      (n = 2022). Only one representative member of each family was included to avoid 
      bias. UAE Emiratis, Arabs of Arabian Gulf Peninsula (AGP), Arabs of South 
      Mediterranean (SMR), North African Arabs (NA), Iranians, and Asians. HLA typing 
      was done by microlymphocytotoxicity method and/or low-resolution polymerase chain 
      reaction-sequence-specific primer techniques. As an individual antigen, HLA-A2 
      had the highest frequency in all populations studied, however, the frequency of 
      the broad antigen A19 surpassed A2 in all the groups except the AGP Arabs and 
      Iranians. B5 was the predominant B antigen in all groups except the SMR and 
      Asians. Amongst the class II broad antigens, DR2 was the most frequent antigen in 
      UAE, AGP Arabs, Iranians, and Asians. The overall frequency of DQ1 was high in 
      all groups except the SMR Arabs who had an almost equal distribution of DQ1 and 
      DQ3. In conclusion, this study indicates that the most frequent antigens in the 
      UAE population are HLA-A19, HLA-A2, HLA-B5, and HLA-DR2. It also sheds light on 
      the similarities between the UAE Emiratis, AGP Arabs, Iranians, and Asians, 
      specially the predominance of DR2 of the class II antigens.
FAU - Valluri, V
AU  - Valluri V
AD  - Immunology and Specialized testing, Mafrag Hospital, Abu Dhabi, UAE.
FAU - Mustafa, M
AU  - Mustafa M
FAU - Santhosh, A
AU  - Santhosh A
FAU - Middleton, D
AU  - Middleton D
FAU - Alvares, M
AU  - Alvares M
FAU - El Haj, E
AU  - El Haj E
FAU - Gumama, O
AU  - Gumama O
FAU - Abdel-Wareth, L
AU  - Abdel-Wareth L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
EIN - Tissue Antigens. 2005 Oct;66(4):341. Valluei, V [corrected to Valluri, V]; 
      Alvales, M [corrected to Alvares, M]; Abdel-Waieth, L [corrected to Abdel-Wareth, 
      L]
MH  - Arabia
MH  - Asian People
MH  - Gene Frequency
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - Humans
MH  - Iran
MH  - Phenotype
MH  - United Arab Emirates/ethnology
EDAT- 2005/07/21 09:00
MHDA- 2005/09/20 09:00
CRDT- 2005/07/21 09:00
PHST- 2005/07/21 09:00 [pubmed]
PHST- 2005/09/20 09:00 [medline]
PHST- 2005/07/21 09:00 [entrez]
AID - TAN441 [pii]
AID - 10.1111/j.1399-0039.2005.00441.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2005 Aug;66(2):107-13. doi: 10.1111/j.1399-0039.2005.00441.x.