PMID- 16029440
OWN - NLM
STAT- MEDLINE
DCOM- 20050919
LR  - 20050720
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 66
IP  - 2
DP  - 2005 Aug
TI  - The recombinant HLA-B*5518 allele supports the evidence of conserved haplotype 
      association of rare alleles.
PG  - 156-9
AB  - Allelic polymorphism of the major histocompatibility complex arises mostly from 
      gene recombination. Intralocus gene recombination usually involves short 
      fragments of DNA leading most commonly to single-nucleotide substitutions and 
      rarely involves large fragments. Here, we report a new recombinant human 
      leukocyte antigen (HLA)-B*5518 allele that has arisen via recombination of a 
      large fragment of DNA spanning more than 70 nucleotides. During routine HLA 
      typing of potential volunteer donors for the National Marrow Donor Program((R)), 
      a new HLA-B allele was identified in two donors from Guam. The allele, B*5518, 
      appears to be a product of recombination between B*5502 and B*40. Exons 1, 3, and 
      4 of the new allele belong to B*5502, whereas part of exon 2 belongs to one of 
      B*40 alleles. Introns 1 and 2 appear to belong to B*55, suggesting that the 
      recombination event may have occurred within the homologous parts of exon 2.
FAU - Lebedeva, T V
AU  - Lebedeva TV
AD  - HLA Laboratory, American Red Cross Blood Services, Dedham, MA 02026, USA. 
      lebedevat@usa. redcross.org
FAU - Huang, A
AU  - Huang A
FAU - Ohashi, M
AU  - Ohashi M
FAU - Sibilia, P
AU  - Sibilia P
FAU - Alosco, S M
AU  - Alosco SM
FAU - Kempenich, J
AU  - Kempenich J
FAU - Yu, N
AU  - Yu N
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - Alleles
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Genotype
MH  - Guam
MH  - HLA-B Antigens/*genetics/immunology
MH  - *Haplotypes
MH  - Humans
MH  - Molecular Sequence Data
MH  - Polymorphism, Single Nucleotide
MH  - *Recombination, Genetic
MH  - Sequence Homology, Nucleic Acid
MH  - Tissue Donors
EDAT- 2005/07/21 09:00
MHDA- 2005/09/20 09:00
CRDT- 2005/07/21 09:00
PHST- 2005/07/21 09:00 [pubmed]
PHST- 2005/09/20 09:00 [medline]
PHST- 2005/07/21 09:00 [entrez]
AID - TAN442 [pii]
AID - 10.1111/j.1399-0039.2005.00442.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2005 Aug;66(2):156-9. doi: 10.1111/j.1399-0039.2005.00442.x.