PMID- 16030068
OWN - NLM
STAT- MEDLINE
DCOM- 20051221
LR  - 20161124
IS  - 0193-1849 (Print)
IS  - 0193-1849 (Linking)
VI  - 289
IP  - 6
DP  - 2005 Dec
TI  - Effects of gender on hepatic HMG-CoA reductase, cholesterol 7alpha-hydroxylase, 
      and LDL receptor in hereditary analbuminemia.
PG  - E993-8
AB  - Hypoalbuminemia is accompanied by hypercholesterolemia in both nephrotic syndrome 
      and hereditary analbuminemia. Hypercholesterolemia is more severe in the female 
      than in the male Nagase analbuminemic rats (NAR). The sex difference in plasma 
      cholesterol diminishes after ovariectomy (OVX) and reappears after estrogen 
      replacement in the NAR. The molecular mechanism responsible for the sex 
      difference in severity of hypercholesterolemia in NAR is not known and was 
      investigated here. To this end, hepatic hydroxylmethylglutaryl (HMG)-CoA 
      reductase, cholesterol 7alpha-hydroxylase, and LDL receptor were determined in 
      male, female, and OVX female NAR and Sprague-Dawley (SD) rats. Plasma 
      cholesterol, triglycerides, and hepatic HMG-CoA reductase activities were greater 
      in both female and male NAR than in SD rats. This was coupled with upregulation 
      of cholesterol 7alpha-hydroxylase in both male and female NAR compared with SD 
      controls. LDL receptor in male NAR was similar to that in male SD rats but was 
      significantly reduced in female NAR. OVX partially, but significantly, reduced 
      plasma cholesterol and triglyceride levels in female NAR. This was coupled with a 
      significant rise in hepatic cholesterol 7alpha-hydroxylase and a modest increase 
      in hepatic LDL receptor. In contrast, OVX resulted in a mild elevation of plasma 
      cholesterol and no significant changes in total hepatic HMG-CoA reductase, 
      cholesterol 7alpha-hydroxylase, or LDL receptor in female SD rats. Thus the 
      greater severity of hypercholesterolemia in the female NAR appears to be due, in 
      part, to a combination of the constrained compensatory upregulation of 
      cholesterol 7alpha-hydroxylase and LDL receptor deficiency.
FAU - Shin, Youngshin
AU  - Shin Y
AD  - Division of Nephrology and Hypertension, UCI Medical Center, University of 
      California-Irvine, 101 The City Drive, Rt. 81, Orange, CA 92868, USA.
FAU - Vaziri, Nosratola D
AU  - Vaziri ND
FAU - Willekes, Nel
AU  - Willekes N
FAU - Kim, Choong H
AU  - Kim CH
FAU - Joles, Jaap A
AU  - Joles JA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20050719
PL  - United States
TA  - Am J Physiol Endocrinol Metab
JT  - American journal of physiology. Endocrinology and metabolism
JID - 100901226
RN  - 0 (Lipoproteins)
RN  - 0 (Receptors, LDL)
RN  - 0 (Serum Albumin)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - EC 1.1.1.- (Hydroxymethylglutaryl CoA Reductases)
RN  - EC 1.14.14.23 (Cholesterol 7-alpha-Hydroxylase)
SB  - IM
MH  - Animals
MH  - Cholesterol/blood
MH  - Cholesterol 7-alpha-Hydroxylase/*metabolism
MH  - Female
MH  - Hydroxymethylglutaryl CoA Reductases/*metabolism
MH  - Lipoproteins/blood
MH  - Liver/*chemistry/enzymology
MH  - Male
MH  - Ovariectomy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, LDL/*analysis
MH  - Serum Albumin/*deficiency/genetics
MH  - *Sex Characteristics
MH  - Triglycerides/blood
EDAT- 2005/07/21 09:00
MHDA- 2005/12/22 09:00
CRDT- 2005/07/21 09:00
PHST- 2005/07/21 09:00 [pubmed]
PHST- 2005/12/22 09:00 [medline]
PHST- 2005/07/21 09:00 [entrez]
AID - 00037.2005 [pii]
AID - 10.1152/ajpendo.00037.2005 [doi]
PST - ppublish
SO  - Am J Physiol Endocrinol Metab. 2005 Dec;289(6):E993-8. doi: 
      10.1152/ajpendo.00037.2005. Epub 2005 Jul 19.