PMID- 16033653
OWN - NLM
STAT- MEDLINE
DCOM- 20061026
LR  - 20191003
IS  - 1475-2875 (Electronic)
IS  - 1475-2875 (Linking)
VI  - 4
DP  - 2005 Jul 20
TI  - The promise and potential challenges of intermittent preventive treatment for 
      malaria in infants (IPTi).
PG  - 33
AB  - Intermittent preventive treatment (IPT) administers a full therapeutic course of 
      an anti-malarial drug at predetermined intervals, regardless of infection or 
      disease status. It is recommended by the World Health Organization (WHO) for 
      protecting pregnant women from the adverse effects of malaria (IPTp) and shows 
      great potential as a strategy for reducing illness from malaria during infancy 
      (IPTi). Administered concurrently with standard immunizations, IPTi is expected 
      to reduce the frequency of clinical disease, but to allow blood-stage infections 
      to occur between treatments, thus allowing parasite-specific immunity to develop. 
      While wide deployment of IPTi is being considered, it is important to assess 
      other potential effects. Transmission conditions, drug choice and administration 
      schedule will likely affect the possibility of post-treatment rebound in child 
      morbidity and mortality and the increased spread of parasite drug resistance and 
      should be considered when implementing IPTi.
FAU - O'Meara, Wendy Prudhomme
AU  - O'Meara WP
AD  - Division of Epidemiology and Population Studies, Fogarty International Center, 
      National Institutes of Health, Bethesda, MD 20892, USA. prudhomw@mail.nih.gov
FAU - Breman, Joel G
AU  - Breman JG
FAU - McKenzie, F Ellis
AU  - McKenzie FE
LA  - eng
GR  - Z99 TW999999/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20050720
PL  - England
TA  - Malar J
JT  - Malaria journal
JID - 101139802
RN  - 0 (Antimalarials)
SB  - IM
MH  - Aging
MH  - Antimalarials/*administration & dosage/pharmacokinetics/*pharmacology/therapeutic 
      use
MH  - Drug Resistance/genetics
MH  - Humans
MH  - Infant
MH  - Malaria/drug therapy/*prevention & control
PMC - PMC1193983
EDAT- 2005/07/22 09:00
MHDA- 2006/10/27 09:00
PMCR- 2005/07/20
CRDT- 2005/07/22 09:00
PHST- 2005/06/14 00:00 [received]
PHST- 2005/07/20 00:00 [accepted]
PHST- 2005/07/22 09:00 [pubmed]
PHST- 2006/10/27 09:00 [medline]
PHST- 2005/07/22 09:00 [entrez]
PHST- 2005/07/20 00:00 [pmc-release]
AID - 1475-2875-4-33 [pii]
AID - 10.1186/1475-2875-4-33 [doi]
PST - epublish
SO  - Malar J. 2005 Jul 20;4:33. doi: 10.1186/1475-2875-4-33.