PMID- 16034072
OWN - NLM
STAT- MEDLINE
DCOM- 20051026
LR  - 20201215
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 175
IP  - 3
DP  - 2005 Aug 1
TI  - Human dendritic cells: potent antigen-presenting cells at the crossroads of 
      innate and adaptive immunity.
PG  - 1373-81
AB  - Dendritic cells (DCs) are specialized, bone marrow-derived leukocytes that are 
      critical to the development of immunity. Investigators have emphasized the role 
      of DCs in initiating adaptive or acquired MHC-restricted, Ag-specific T cell 
      responses. More recent evidence supports important roles for DCs in the onset of 
      innate immunity and peripheral tolerance. Progress in the generation of DCs from 
      defined hemopoietic precursors in vitro has revealed the heterogeneity of these 
      APCs and their attendant divisions of labor. This review will address these 
      developments in an attempt to integrate the activities of different DCs in 
      coordinating innate and adaptive immunity.
FAU - Rossi, Marco
AU  - Rossi M
AD  - Laboratory of Cellular Immunobiology, Division of Hematologic Oncology, 
      Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New 
      York 10021, USA.
FAU - Young, James W
AU  - Young JW
LA  - eng
GR  - P01 CA23766/CA/NCI NIH HHS/United States
GR  - P01 CA59350/CA/NCI NIH HHS/United States
GR  - R01 CA83070/CA/NCI NIH HHS/United States
GR  - R21 CA105718/CA/NCI NIH HHS/United States
GR  - R21 CA97714/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
SB  - IM
MH  - Antigen Presentation/*immunology
MH  - Dendritic Cells/classification/*immunology/*metabolism/transplantation
MH  - Humans
MH  - Immunity, Cellular
MH  - Immunity, Innate
MH  - Immunotherapy, Adoptive/methods/trends
RF  - 135
EDAT- 2005/07/22 09:00
MHDA- 2005/10/27 09:00
CRDT- 2005/07/22 09:00
PHST- 2005/07/22 09:00 [pubmed]
PHST- 2005/10/27 09:00 [medline]
PHST- 2005/07/22 09:00 [entrez]
AID - 175/3/1373 [pii]
AID - 10.4049/jimmunol.175.3.1373 [doi]
PST - ppublish
SO  - J Immunol. 2005 Aug 1;175(3):1373-81. doi: 10.4049/jimmunol.175.3.1373.