PMID- 16034537 OWN - NLM STAT- MEDLINE DCOM- 20051207 LR - 20181113 IS - 0941-1291 (Print) IS - 0941-1291 (Linking) VI - 35 IP - 8 DP - 2005 TI - Human leukocyte antigen antibodies for monitoring transplant patients. PG - 605-12 AB - Human leukocyte antigen (HLA) antibody-mediated hyperacute rejection has dramatically decreased since the clinical introduction of crossmatch technology. However, the role of HLA antibody in acute and chronic rejection remains unclear. In this article, we cite publications to show the correlation between HLA antibody and allograft rejection. Potential pathological mechanisms of antibody-mediated rejection are also proposed and the rationale of commonly used HLA antibody detection techniques are introduced. The advantages and disadvantages of these technologies are further discussed in detail. We conclude that owing to the recent availability of improved antibody detection methods, a causal relationship between HLA antibodies and allograft rejection is now considered to exist. FAU - Cai, Junchao AU - Cai J AD - Terasaki Foundation Laboratory, 11570 West Olympic Boulevard, Los Angeles, CA, 90064, USA. FAU - Terasaki, Paul I AU - Terasaki PI LA - eng PT - Journal Article PT - Review PL - Japan TA - Surg Today JT - Surgery today JID - 9204360 RN - 0 (HLA Antigens) SB - IM MH - Graft Rejection/*immunology MH - HLA Antigens/*immunology MH - Humans RF - 99 EDAT- 2005/07/22 09:00 MHDA- 2005/12/13 09:00 CRDT- 2005/07/22 09:00 PHST- 2004/09/07 00:00 [received] PHST- 2005/01/18 00:00 [accepted] PHST- 2005/07/22 09:00 [pubmed] PHST- 2005/12/13 09:00 [medline] PHST- 2005/07/22 09:00 [entrez] AID - 10.1007/s00595-005-3015-6 [doi] PST - ppublish SO - Surg Today. 2005;35(8):605-12. doi: 10.1007/s00595-005-3015-6.