PMID- 16034720
OWN - NLM
STAT- MEDLINE
DCOM- 20050927
LR  - 20161124
IS  - 0018-5043 (Print)
IS  - 0018-5043 (Linking)
VI  - 37
IP  - 7
DP  - 2005 Jul
TI  - Aldosterone inhibits uncoupling protein-1, induces insulin resistance, and 
      stimulates proinflammatory adipokines in adipocytes.
PG  - 455-9
AB  - Aldosterone is a mineralocorticoid hormone that regulates blood pressure and 
      salt/water balance. Increased aldosterone levels are found in states of disturbed 
      energy balance such as the metabolic syndrome. Adipose tissue has been recognized 
      to play a pivotal role in the regulation of energy homeostasis. We investigated 
      direct aldosterone effects on brown adipocyte function. Aldosterone 
      dose-dependently inhibited expression of uncoupling protein-1 (UCP-1) by 30% (p < 
      0.01). Furthermore, aldosterone dose-dependently impaired insulin-induced glucose 
      uptake by about 25% (p < 0.01). On a transcriptional level, mRNA of the 
      proinflammatory adipokines leptin and monocyte chemoattractant protein-1 (MCP-1) 
      was increased by 5,000% and 40%, respectively, by aldosterone exposure (p < 
      0.05). This study demonstrates that aldosterone directly impacts on major adipose 
      functions including stimulation of proinflammatory adipokines.
FAU - Kraus, D
AU  - Kraus D
AD  - Department of Internal Medicine I, University of Lubeck, 23538 Lubeck, Germany.
FAU - Jager, J
AU  - Jager J
FAU - Meier, B
AU  - Meier B
FAU - Fasshauer, M
AU  - Fasshauer M
FAU - Klein, J
AU  - Klein J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Horm Metab Res
JT  - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et 
      metabolisme
JID - 0177722
RN  - 0 (Carrier Proteins)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Insect Hormones)
RN  - 0 (Ion Channels)
RN  - 0 (Leptin)
RN  - 0 (Membrane Proteins)
RN  - 0 (Mitochondrial Proteins)
RN  - 0 (Oligopeptides)
RN  - 0 (RNA, Messenger)
RN  - 0 (Ucp1 protein, mouse)
RN  - 0 (Uncoupling Protein 1)
RN  - 0 (adipokinetic hormone)
RN  - 4964P6T9RB (Aldosterone)
RN  - IY9XDZ35W2 (Glucose)
RN  - SZB83O1W42 (Pyrrolidonecarboxylic Acid)
SB  - IM
MH  - Adipocytes/drug effects/*metabolism
MH  - Adipose Tissue, Brown/cytology/drug effects/metabolism
MH  - Aldosterone/*pharmacology
MH  - Animals
MH  - Blotting, Western
MH  - Carrier Proteins/*antagonists & inhibitors
MH  - Chemokine CCL2/biosynthesis
MH  - Dose-Response Relationship, Drug
MH  - Energy Metabolism/drug effects
MH  - Gene Expression/drug effects
MH  - Glucose/metabolism
MH  - Inflammation/*pathology
MH  - Insect Hormones/*biosynthesis
MH  - Insulin Resistance/*physiology
MH  - Ion Channels
MH  - Leptin/biosynthesis
MH  - Membrane Proteins/*antagonists & inhibitors
MH  - Mice
MH  - Mitochondrial Proteins
MH  - Oligopeptides/*biosynthesis
MH  - Pyrrolidonecarboxylic Acid/*analogs & derivatives
MH  - RNA, Messenger/biosynthesis
MH  - Thermogenesis/drug effects
MH  - Uncoupling Protein 1
EDAT- 2005/07/22 09:00
MHDA- 2005/09/28 09:00
CRDT- 2005/07/22 09:00
PHST- 2005/07/22 09:00 [pubmed]
PHST- 2005/09/28 09:00 [medline]
PHST- 2005/07/22 09:00 [entrez]
AID - 10.1055/s-2005-870240 [doi]
PST - ppublish
SO  - Horm Metab Res. 2005 Jul;37(7):455-9. doi: 10.1055/s-2005-870240.