PMID- 16035353
OWN - NLM
STAT- MEDLINE
DCOM- 20051007
LR  - 20190720
IS  - 0021-9673 (Print)
IS  - 0021-9673 (Linking)
VI  - 1082
IP  - 2
DP  - 2005 Aug 5
TI  - Microwave assisted extraction followed by gas chromatography with tandem mass 
      spectrometry for the determination of triclosan and two related chlorophenols in 
      sludge and sediments.
PG  - 128-35
AB  - A procedure for the determination of 2-(2,4-dichlorophenoxy)-5-chlorophenol 
      (Triclosan) and two possible transformation compounds, 2,4-dichlorophenol 
      (2,4-DCP) and 2,4,6-trichlorophenol (2,4,6-TCP), in sludge from sewage treatment 
      plants (STP) and sediments is presented. Extraction was performed using an 
      acetone:methanol (1:1) mixture under the action of a microwave field. The 
      centrifuged supernatant was diluted with a NaOH aqueous solution and twice 
      extracted with n-hexane for removing neutral and basic interferences. The aqueous 
      layer was acidified and processed as a waste water sample. After concentration 
      analytes were silylated and determined by gas chromatography with tandem mass 
      spectrometry (GC-MS/MS). Influence of experimental conditions on the yield of the 
      extraction process and on the efficiency of the further clean-up step was 
      thoroughly evaluated. Performance of MS/MS detection in comparison to single MS 
      is described. Under final working conditions quantification limits between 0.4 
      and 0.8 ng/g and recoveries from 78% to 106% were obtained. The method was 
      applied to the analysis of several sludge and sediment samples. Only low levels 
      of TCS were detected in some of the sediments; however, all three compounds were 
      found in sludge samples at concentrations ranging from 7 to 316 ng/g, in the case 
      of chlorophenols, and from 420 to 5400 ng/g, for Triclosan.
FAU - Morales, S
AU  - Morales S
AD  - Departamento de Quimica Analitica, Nutricion y Bromatologia, Instituto de 
      Investigacin y Analisis Alimentario, Universidad de Santiago de Compostela, 
      Santiago de Compostela 15782, Spain.
FAU - Canosa, P
AU  - Canosa P
FAU - Rodriguez, I
AU  - Rodriguez I
FAU - Rubi, E
AU  - Rubi E
FAU - Cela, R
AU  - Cela R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Chlorophenols)
RN  - 0 (Sewage)
RN  - 4NM5039Y5X (Triclosan)
RN  - MHS8C5BAUZ (2,4,6-trichlorophenol)
RN  - R669TG1950 (2,4-dichlorophenol)
SB  - IM
MH  - Chemical Fractionation
MH  - Chlorophenols/*analysis
MH  - Gas Chromatography-Mass Spectrometry/*methods
MH  - Geologic Sediments/*chemistry
MH  - Microwaves
MH  - Reproducibility of Results
MH  - Sewage/*chemistry
MH  - Triclosan/*analysis
EDAT- 2005/07/23 09:00
MHDA- 2005/10/08 09:00
CRDT- 2005/07/23 09:00
PHST- 2005/07/23 09:00 [pubmed]
PHST- 2005/10/08 09:00 [medline]
PHST- 2005/07/23 09:00 [entrez]
AID - S0021-9673(05)01102-7 [pii]
AID - 10.1016/j.chroma.2005.05.059 [doi]
PST - ppublish
SO  - J Chromatogr A. 2005 Aug 5;1082(2):128-35. doi: 10.1016/j.chroma.2005.05.059.