PMID- 16035398
OWN - NLM
STAT- MEDLINE
DCOM- 20051107
LR  - 20151119
IS  - 1368-504X (Print)
IS  - 1368-504X (Linking)
IP  - 144
DP  - 2004 Oct
TI  - Effect of nimesulide on the serum levels of hyaluronan and stromelysin-1 in 
      patients with osteoarthritis: a pilot study.
PG  - 13-9
AB  - This prospective preliminary single-blind study was conducted in patients 
      suffering from osteoarthritis (OA) and requiring non-steroidal anti-inflammatory 
      drugs (NSAIDs) to determine to what extent nimesulide (200 mg/day) and ibuprofen 
      (1200 mg/day) could induce significant changes in the serum levels of matrix 
      metalloproteinase-3 (MMP-3), tissue inhibitor-1 of MMPs (TIMP-1), hyaluronan (HA) 
      and YKL-40 after a therapeutic time period of 28 days. The four biochemical 
      parameters were assessed by using immunoassays. Nimesulide significantly reduced 
      the serum levels of both HA and MMP-3, whereas ibuprofen increased moderately but 
      significantly the serum concentrations of MMP-3 and had no effect on the serum 
      concentrations of HA. The two NSAIDs were unable to change the serum levels of 
      both TIMP-1 and YKL-40. These results suggest that nimesulide might have a 
      favourable effect on the metabolism of OA joints.
FAU - Bevilacqua, Maurizio
AU  - Bevilacqua M
AD  - Department of Endocrinology, Hospital Luigi Sacco, 20157 Milan, Italy.
FAU - Devogelaer, Jean-Pierre
AU  - Devogelaer JP
FAU - Righini, Velella
AU  - Righini V
FAU - Famaey, Jean-Pierre
AU  - Famaey JP
FAU - Manicourt, Daniel-Henri
AU  - Manicourt DH
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Int J Clin Pract Suppl
JT  - International journal of clinical practice. Supplement
JID - 9712380
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Biomarkers)
RN  - 0 (Sulfonamides)
RN  - 9004-61-9 (Hyaluronic Acid)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - V4TKW1454M (nimesulide)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use
MH  - Biomarkers/blood
MH  - Female
MH  - Humans
MH  - Hyaluronic Acid/*blood
MH  - Male
MH  - Matrix Metalloproteinase 3/*blood
MH  - Middle Aged
MH  - Osteoarthritis/blood/*drug therapy
MH  - Pilot Projects
MH  - Single-Blind Method
MH  - Sulfonamides/*therapeutic use
EDAT- 2005/07/23 09:00
MHDA- 2005/11/08 09:00
CRDT- 2005/07/23 09:00
PHST- 2005/07/23 09:00 [pubmed]
PHST- 2005/11/08 09:00 [medline]
PHST- 2005/07/23 09:00 [entrez]
PST - ppublish
SO  - Int J Clin Pract Suppl. 2004 Oct;(144):13-9.