PMID- 16038023
OWN - NLM
STAT- MEDLINE
DCOM- 20051012
LR  - 20190430
IS  - 1007-9327 (Print)
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Linking)
VI  - 11
IP  - 28
DP  - 2005 Jul 28
TI  - Treatment of uncomplicated reflux disease.
PG  - 4291-9
AB  - Uncomplicated reflux disease comprises the non-erosive reflux disease (NERD) and 
      erosive reflux disease (ERD). The objectives of treatment are the adequate 
      control of symptoms with restoration of quality of life, healing of lesions and 
      prevention of relapse. Treatment of NERD consists in the administration of proton 
      pump inhibitors (PPI) for 2-4 wk, although patients with NERD show an overall 
      poorer response to PPI treatment than patients with ERD owing to the fact that 
      patients with NERD do not form a pathophysiologically homogenous group. For 
      long-term management on-demand treatment with a PPI is probably the best option. 
      In patients with ERD, therapy with a standard dose PPI for 4-8 wk is always 
      recommended. Long-term treatment of ERD is applied either intermittently or as 
      continuous maintenance treatment with an attempt to reduce the daily dosage of 
      the PPI (step-down principle). In selected patients requiring long-term PPI 
      treatment, antireflux surgery is an alternative option. In patients with 
      troublesome reflux symptoms and without alarming features empirical PPI therapy 
      is another option for initial management. Therapy should be withdrawn after 
      initial success. In the case of relapse, the long-term care depends on a careful 
      risk assessment and the response to PPI therapy.
FAU - Labenz, Joachim
AU  - Labenz J
AD  - Jung-Stilling Hospital, Wichern str. 40, D-57074 Siegen, Germany. 
      j.labenz@t-online.de
FAU - Malfertheiner, Peter
AU  - Malfertheiner P
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Anti-Ulcer Agents/*therapeutic use
MH  - Duodenogastric Reflux/*drug therapy/*surgery
MH  - Humans
MH  - *Proton Pump Inhibitors
PMC - PMC4434651
EDAT- 2005/07/23 09:00
MHDA- 2005/10/13 09:00
PMCR- 2005/07/28
CRDT- 2005/07/23 09:00
PHST- 2005/07/23 09:00 [pubmed]
PHST- 2005/10/13 09:00 [medline]
PHST- 2005/07/23 09:00 [entrez]
PHST- 2005/07/28 00:00 [pmc-release]
AID - 10.3748/wjg.v11.i28.4291 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2005 Jul 28;11(28):4291-9. doi: 10.3748/wjg.v11.i28.4291.