PMID- 16038589
OWN - NLM
STAT- MEDLINE
DCOM- 20050915
LR  - 20190917
IS  - 0033-7587 (Print)
IS  - 0033-7587 (Linking)
VI  - 164
IP  - 2
DP  - 2005 Aug
TI  - Monte Carlo simulation of base and nucleotide excision repair of clustered DNA 
      damage sites. I. Model properties and predicted trends.
PG  - 180-93
AB  - DNA is constantly damaged through endogenous processes and by exogenous agents, 
      such as ionizing radiation. Base excision repair (BER) and nucleotide excision 
      repair (NER) help maintain the stability of the genome by removing many different 
      types of DNA damage. We present a Monte Carlo excision repair (MCER) model that 
      simulates key steps in the short-patch and long-patch BER pathways and the NER 
      pathway. The repair of both single and clustered damages, except double-strand 
      breaks (DSBs), is simulated in the MCER model. Output from the model includes 
      estimates of the probability that a cluster is repaired correctly, the fraction 
      of the clusters converted into DSBs through the action of excision repair 
      enzymes, the fraction of the clusters repaired with mutations, and the expected 
      number of repair cycles needed to completely remove a clustered damage site. The 
      quantitative implications of alternative hypotheses regarding the postulated 
      repair mechanisms are investigated through a series of parameter sensitivity 
      studies. These sensitivity studies are also used to help define the putative 
      repair characteristics of clustered damage sites other than DSBs.
FAU - Semenenko, V A
AU  - Semenenko VA
AD  - Purdue University, School of Health Sciences, West Lafayette, Indiana 47907-2051, 
      USA.
FAU - Stewart, R D
AU  - Stewart RD
FAU - Ackerman, E J
AU  - Ackerman EJ
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Radiat Res
JT  - Radiation research
JID - 0401245
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - DNA/biosynthesis
MH  - *DNA Damage
MH  - *DNA Repair
MH  - Linear Energy Transfer
MH  - *Monte Carlo Method
EDAT- 2005/07/26 09:00
MHDA- 2005/09/16 09:00
CRDT- 2005/07/26 09:00
PHST- 2005/07/26 09:00 [pubmed]
PHST- 2005/09/16 09:00 [medline]
PHST- 2005/07/26 09:00 [entrez]
AID - RR3402 [pii]
AID - 10.1667/rr3402 [doi]
PST - ppublish
SO  - Radiat Res. 2005 Aug;164(2):180-93. doi: 10.1667/rr3402.