PMID- 16038628
OWN - NLM
STAT- MEDLINE
DCOM- 20060503
LR  - 20061115
IS  - 1671-4083 (Print)
IS  - 1671-4083 (Linking)
VI  - 26
IP  - 8
DP  - 2005 Aug
TI  - Blood pressure variability and baroreflex sensitivity are not different in 
      spontaneously hypertensive rats and stroke-prone spontaneously hypertensive rats.
PG  - 959-62
AB  - AIM: To demonstrate and compare hemodynamic phenotypes of blood pressure (BP), 
      blood pressure variability (BPV) and baroreflex sensitivity (BRS) in genetic 
      hypertensive rats. METHODS: BP was recorded continuously in conscious, freely 
      moving rats using a computerized technique. BPV was expressed as the standard 
      deviation of beat-to-beat BP values during a 1-h period. BRS was determined by 
      measuring the heart period prolongation in response to the elevation in BP 
      produced by an intravenous injection of phenylephrine. RESULTS: Body weight and 
      heart period were not different between spontaneously hypertensive rats (SHR) and 
      stroke-prone spontaneously hypertensive rats (SHR-SP) at the age of 15 weeks. The 
      BP level was markedly higher in SHR-SP than SHR, whereas there were no 
      significant differences in BPV and BRS. Quantitatively, systolic, diastolic and 
      mean BP were significantly elevated by 36.9%, 42.9% and 39.5%, respectively, in 
      SHR-SP compared with SHR (P < 0.01). However, their variabilities were elevated 
      only by 14.0%, 0.4% and 10.1%, respectively, without statistical significance (P 
      > 0.05). CONCLUSION: BPV and BRS were not changed in parallel with the BP 
      alterations in SHR and SHR-SP.
FAU - Zhan, Lin-shu
AU  - Zhan LS
AD  - Department of Pharmacology, Second Military Medical University, Shanghai 200433, 
      China.
FAU - Guan, Yun-feng
AU  - Guan YF
FAU - Su, Ding-feng
AU  - Su DF
FAU - Miao, Chao-yu
AU  - Miao CY
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Acta Pharmacol Sin
JT  - Acta pharmacologica Sinica
JID - 100956087
SB  - IM
MH  - Animals
MH  - Baroreflex/*physiology
MH  - Blood Pressure/*physiology
MH  - Body Weight/physiology
MH  - Heart Rate/physiology
MH  - Hypertension/*physiopathology
MH  - Male
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred Strains
MH  - Species Specificity
EDAT- 2005/07/26 09:00
MHDA- 2006/05/04 09:00
CRDT- 2005/07/26 09:00
PHST- 2005/07/26 09:00 [pubmed]
PHST- 2006/05/04 09:00 [medline]
PHST- 2005/07/26 09:00 [entrez]
AID - 10.1111/j.1745-7254.2005.00144.x [doi]
PST - ppublish
SO  - Acta Pharmacol Sin. 2005 Aug;26(8):959-62. doi: 10.1111/j.1745-7254.2005.00144.x.