PMID- 16038765
OWN - NLM
STAT- MEDLINE
DCOM- 20060921
LR  - 20071214
IS  - 1532-2742 (Electronic)
IS  - 0163-4453 (Linking)
VI  - 51
IP  - 2
DP  - 2005 Aug
TI  - Major histocompatibility complex and central nervous system involvement by 
      paracoccidioidomycosis.
PG  - 140-3
AB  - Paracoccidioidomycosis (PCM) is a chronic granulomatous infectious disease, whose 
      etiologic agent is the fungus Paracoccidioides brasiliensis. The central nervous 
      system (CNS) involvement with paracoccidioidomycosis (NPCM) occurs more 
      frequently than has been admitted in the past. There are some major 
      histocompatibility complex antigen association studies with systemic 
      paracoccidioidomycosis. Some indicate a positive association with HLA antigens, 
      but there is no study with the involvement of the CNS. To investigate why not all 
      cases of systemic PCM show the involvement of the CNS and whether genetic factors 
      are involved, we studied 6 patients with NPCM, from the neuroinfection outpatient 
      clinic. The patients were typed for class I and class II antigens by a 
      microlymphocytoxity standard test. The HLA antigen frequencies found in this 
      study in patients with NPCM were not different from the alleles frequencies 
      observed in the Parana population.
FAU - de Almeida, Sergio Monteiro
AU  - de Almeida SM
AD  - Neurology Unit, Hospital de Clinicas, Federal University of Parana, Especialidade 
      de Neurologia, Rua General Carneiro, 181, sala 1236, 80060-900 Curitiba, PR, 
      Brazil. sergio.ma@pop.com.br
FAU - Rebelatto, Carmen Lucia Kuniyoshi
AU  - Rebelatto CL
FAU - Queiroz-Telles, Flavio
AU  - Queiroz-Telles F
FAU - Werneck, Lineu Cesar
AU  - Werneck LC
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - J Infect
JT  - The Journal of infection
JID - 7908424
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Causality
MH  - Central Nervous System Fungal Infections/*etiology/immunology
MH  - HLA Antigens/*analysis
MH  - Humans
MH  - *Major Histocompatibility Complex/genetics/immunology
MH  - Male
MH  - Middle Aged
MH  - Paracoccidioidomycosis/*complications/diagnosis/immunology
MH  - Phenotype
EDAT- 2005/07/26 09:00
MHDA- 2006/09/22 09:00
CRDT- 2005/07/26 09:00
PHST- 2004/06/21 00:00 [accepted]
PHST- 2005/07/26 09:00 [pubmed]
PHST- 2006/09/22 09:00 [medline]
PHST- 2005/07/26 09:00 [entrez]
AID - S0163-4453(04)00146-X [pii]
AID - 10.1016/j.jinf.2004.06.008 [doi]
PST - ppublish
SO  - J Infect. 2005 Aug;51(2):140-3. doi: 10.1016/j.jinf.2004.06.008.